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N A Strutyns'ka et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 3-10 (2013-05-30)
In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, and H2S biosynthesis substrate, L-cysteine, on the sensitivity
Valerio Leoni et al.
Journal of lipid research, 46(2), 191-195 (2004-12-04)
In a recent publication [Diestel, A., O. Aktas, D. Hackel, I. Hake, S. Meier, C. S. Raine, R. Nitsch, F. Zipp, and O. Ullrich. 2003. Activation of microglial poly (ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination
Y Zhang et al.
British journal of cancer, 110(1), 71-82 (2013-12-11)
Heat shock protein 90 (HSP90) has a key role in the maintenance of the cellular proteostasis. However, HSP90 is also involved in stabilisation of oncogenic client proteins and facilitates oncogene addiction and cancer cell survival. The development of HSP90 inhibitors
David Balchin et al.
Biochemistry, 52(51), 9394-9402 (2013-11-26)
Protein S-nitrosation is a post-translational modification that regulates the function of more than 500 human proteins. Despite its apparent physiological significance, S-nitrosation is poorly understood at a molecular level. Here, we investigated the effect of S-nitrosation on the activity, structure
Huifang Xu et al.
The Journal of biological chemistry, 289(19), 13565-13574 (2014-03-29)
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by collagen. DDR activation does not appear to occur by the common mechanism of ligand-induced receptor dimerization: the DDRs form stable noncovalent dimers in the absence
Sun-A Cho et al.
Toxicology letters, 225(1), 185-191 (2013-12-24)
Cosmetics are normally composed of various ingredients. Some cosmetic ingredients can act as chemical haptens reacting toward proteins or peptides of human skin and they can provoke an immunologic reaction, called as skin sensitization. This haptenation process is very important
Hongli Mao et al.
Colloids and surfaces. B, Biointerfaces, 126, 63-69 (2014-12-30)
Three-dimensional (3D) porous collagen sponges incorporated with single-walled carbon nanotubes (SWCNTs) were prepared and used for 3D culture of bovine articular chondrocytes (BACs). The pore structures of the sponges were controlled by using ice particulates as a porogen material. The
Ting Xie et al.
Nature chemical biology, 10(12), 1006-1012 (2014-10-20)
Her3 (also known as ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be 'undruggable' using ATP-competitive small molecules because it lacks appreciable kinase activity. Here we
Ye Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 11929-11947 (2014-09-05)
The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function. To better understand the functions and interactions of the cell types that comprise these classes, we acutely purified representative populations of neurons, astrocytes, oligodendrocyte
A Cristina S Rocha et al.
Ecotoxicology and environmental safety, 109, 152-160 (2014-09-07)
Metals are known to induce oxidative stress in plant cells. Antioxidant thiolic compounds are known to play an important role in plants׳ defence mechanisms against metal toxicity but, regarding salt marsh plants, their role is still very poorly understood. In
Hua He et al.
Luminescence : the journal of biological and chemical luminescence, 29(7), 837-845 (2014-01-18)
We compared the effects of several ligands frequently used in aqueous synthesis, including L-cysteine, L-cysteine hydrochloride, N-acetyl-L-cysteine (NAC), glutathione and 3-mercaptopropionic acid, for microwave synthesis of CdTe quantum dots (QDs) in a sealed vessel with varied temperatures and times, and
Jaeho Lee et al.
Biochemical and biophysical research communications, 443(2), 483-488 (2013-12-11)
Coprisin is a 43-mer defensin-like peptide from the dung beetle, Copris tripartitus. CopA3 (LLCIALRKK-NH₂), a 9-mer peptide containing a single free cysteine residue at position 3 of its sequence, was derived from the α-helical region of coprisin and exhibits potent
J G Pilitsis et al.
Brain research, 985(2), 198-201 (2003-09-12)
Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) from patients with ischemic and hemorrhagic stroke (n=25) and in contemporary controls (n=73) were examined using HPLC. Concentrations of CSF FFAs from ischemic and hemorrhagic stroke patients obtained within 48 h
Jiahua Li et al.
American journal of physiology. Cell physiology, 305(2), C190-C196 (2013-05-17)
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these
Fiona E Freeman et al.
Tissue engineering. Part A, 21(7-8), 1320-1332 (2015-01-16)
Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo osteogenic differentiation and mineralization in vitro and
Kazuki Ohno et al.
Biochemical and biophysical research communications, 456(1), 245-249 (2014-12-03)
Hydrogen sulfide (H2S) is a gaseous regulatory factor produced by several enzymes, and plays a pivotal role in processes such as proliferation or vasodilation. Recent reports demonstrated the physiological and pathophysiological functions of H2S in neurons. PTEN is a target
Shaun M Cote et al.
Biochemistry, 52(51), 9141-9154 (2013-11-26)
NEMO (NF-κB essential modulator) associates with catalytic subunits IKKα and IKKβ to form the IκB kinase (IKK) complex and is a key regulator of NF-κB pathway signaling. Biochemical and structural characterization of NEMO has been challenging, however, leading to conflicting
Helena Lucena-Padrós et al.
International journal of food microbiology, 190, 72-78 (2014-09-10)
We have genotyped a total of 1045 microbial isolates obtained along the fermentation time of Spanish-style green table olives from the fermentation yards (patios) of two large manufacturing companies in the Province of Sevilla, south of Spain. Genotyping was carried
Qunfei Zhao et al.
Nature, 518(7537), 115-119 (2015-01-22)
Low-molecular-mass thiols in organisms are well known for their redox-relevant role in protection against various endogenous and exogenous stresses. In eukaryotes and Gram-negative bacteria, the primary thiol is glutathione (GSH), a cysteinyl-containing tripeptide. In contrast, mycothiol (MSH), a cysteinyl pseudo-disaccharide
Sushil K Jain
Canadian journal of physiology and pharmacology, 90(8), 1061-1064 (2012-07-13)
Diabetes remains a major public health issue. According to the American Diabetes Association, 23.5 million, or 10.7% of people in the USA aged 20 years and older, have diabetes. Type-2 diabetes is treated both by controlling the diet and with
Mikko T Nieminen et al.
PloS one, 9(5), e97864-e97864 (2014-05-29)
The ability of C. albicans to form biofilms is a major virulence factor and a challenge for management. This is evident in biofilm-associated chronic oral-oesophageal candidosis, which has been shown to be potentially carcinogenic in vivo. We have previously shown
Veerle Kersemans et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 46(3), 532-539 (2005-03-08)
The application of 123I-3-iodo-alpha-methyltyrosine is limited to diagnosis of brain tumors due to its marked long-term uptake in kidneys. In vitro evaluation of 125I-2-iodo-L-phenylalanine showed high uptake in R1M cells by L-type amino acid transport system 1 (LAT1). This study
Hong Sik Yoo et al.
Journal of toxicology and environmental health. Part A, 78(1), 32-49 (2014-11-27)
Trichloroethylene (TCE) is a well-known environmental and occupational toxicant that is classified as carcinogenic to humans based on the epidemiological evidence of an association with higher risk of renal-cell carcinoma. A number of scientific issues critical for assessing human health
Z Li et al.
Letters in applied microbiology, 59(6), 615-620 (2014-08-26)
Cysteine phytase is the main phytate-degrading enzyme of ruminant animals. To explore the genetic diversity and dynamic expression profile of cysteine phytase in sheep rumen during a feeding cycle, four transcript (0, 4, 9 and 16 h after feeding) and one
Maria V Yelshanskaya et al.
Science (New York, N.Y.), 345(6200), 1070-1074 (2014-08-12)
Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the central nervous system and function by opening their ion channel in response to binding of agonist glutamate. Here, we report a structure of a homotetrameric rat GluA2 receptor in complex
Li Zhang et al.
Biochimica et biophysica acta, 1838(7), 1809-1816 (2014-03-25)
The Escherichia coli inner membrane protein CysZ mediates the sulfate uptake subsequently utilized for the synthesis of sulfur-containing compounds in cells. Here we report the purification and functional characterization of CysZ. Using Isothermal Titration Calorimetry, we have observed interactions between
Muhammad Azhar Sherkheli et al.
Pakistan journal of pharmaceutical sciences, 26(3), 431-438 (2013-04-30)
TRPV3 ion channels mediate thermo-transduction, nociception, inflammation and dermatitis in mammals. TRPV1-4 proteins have been shown to have conserved cysteine-residues in the pore-forming regions. These residues participate in channel activation via S-nitrosylation of channel proteins. Camphor is a commonly used
Nikolaos Psychogios et al.
PloS one, 6(2), e16957-e16957 (2011-03-02)
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal
Jörg Sandmann et al.
FEBS letters, 579(19), 4119-4124 (2005-07-19)
The transport of various S-nitrosothiols, NO and NO donors in human red blood cells (RBC) and the formation of erythrocytic S-nitrosoglutathione were investigated. Of the NO species tested only S-nitrosocysteine was found to form S-nitrosoglutathione in the RBC cytosol. L-Serine
Biochemistry: Elusive source of sulfur unravelled.
Charles E Melançon
Nature, 518(7537), 45-46 (2015-01-22)
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