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Byung Sun Park et al.
Journal of neurochemistry, 132(2), 230-242 (2014-08-16)
Hydrogen sulfide (H2 S) functions as a physiological gas transmitter in both normal and pathophysiological cellular events. H2 S is produced from substances by three enzymes: cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST). In human tissues, these
Carolina Pereira Tavares et al.
Biochimica et biophysica acta, 1844(4), 810-817 (2014-03-04)
MYB proteins are a family of transcription factors that play an important role in plant development and regulatory defense processes. Arabidopsis thaliana MYB30 (AtMYB30), a member of this protein family, is involved in cell death processes during the hypersensitive response
T M Jeitner et al.
Journal of neurochemistry, 79(5), 1109-1112 (2001-12-12)
Pathological-length polyglutamine (Q(n)) expansions, such as those that occur in the huntingtin protein (htt) in Huntington's disease (HD), are excellent substrates for tissue transglutaminase in vitro, and transglutaminase activity is increased in post-mortem HD brain. However, direct evidence for the
C Syburra et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 71(3), 112-115 (1999-12-28)
It is well known that brain and nervous system cells are prone to oxidative damage because of their relatively low content of antioxidants, especially enzymatic ones, and of the high levels of both membrane polyunsaturated fatty acids (PUFA) and iron
Alan Tseng et al.
Cartilage, 5(4), 241-251 (2015-06-13)
Our goal was to engineer cartilage in vivo using auricular chondrocytes that underwent clinically relevant expansion and using methodologies that could be easily translated into health care practice. Sheep and human chondrocytes were isolated from auricular cartilage biopsies and expanded
Nitric oxide quenches the fire in heart mitochondria.
Paul T Schumacker
Nature medicine, 19(6), 666-667 (2013-06-08)
Pravin Kesarwani et al.
Cancer research, 74(21), 6036-6047 (2014-08-29)
Ex vivo-expanded CD8(+) T cells used for adoptive immunotherapy generally acquire an effector memory-like phenotype (TEM cells). With regard to therapeutic applications, two undesired features of this phenotype in vivo are limited persistence and reduced antitumor efficacy, relative to CD8(+)
David Balchin et al.
Biochemistry, 52(51), 9394-9402 (2013-11-26)
Protein S-nitrosation is a post-translational modification that regulates the function of more than 500 human proteins. Despite its apparent physiological significance, S-nitrosation is poorly understood at a molecular level. Here, we investigated the effect of S-nitrosation on the activity, structure
Huifang Xu et al.
The Journal of biological chemistry, 289(19), 13565-13574 (2014-03-29)
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by collagen. DDR activation does not appear to occur by the common mechanism of ligand-induced receptor dimerization: the DDRs form stable noncovalent dimers in the absence
Maria V Yelshanskaya et al.
Science (New York, N.Y.), 345(6200), 1070-1074 (2014-08-12)
Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the central nervous system and function by opening their ion channel in response to binding of agonist glutamate. Here, we report a structure of a homotetrameric rat GluA2 receptor in complex
Hong Sik Yoo et al.
Journal of toxicology and environmental health. Part A, 78(1), 32-49 (2014-11-27)
Trichloroethylene (TCE) is a well-known environmental and occupational toxicant that is classified as carcinogenic to humans based on the epidemiological evidence of an association with higher risk of renal-cell carcinoma. A number of scientific issues critical for assessing human health
Z Li et al.
Letters in applied microbiology, 59(6), 615-620 (2014-08-26)
Cysteine phytase is the main phytate-degrading enzyme of ruminant animals. To explore the genetic diversity and dynamic expression profile of cysteine phytase in sheep rumen during a feeding cycle, four transcript (0, 4, 9 and 16 h after feeding) and one
Melissa A Badding et al.
PloS one, 9(6), e101310-e101310 (2014-07-01)
Welding processes that generate fumes containing toxic metals, such as hexavalent chromium (Cr(VI)), manganese (Mn), and nickel (Ni), have been implicated in lung injury, inflammation, and lung tumor promotion in animal models. While federal regulations have reduced permissible worker exposure
Yoshiaki Nishiya et al.
Bioscience, biotechnology, and biochemistry, 69(11), 2244-2246 (2005-11-25)
We have developed a new enzymatic assay for determining L-cysteine concentration. The method involves the use of betaC-S lyase from Streptococcus anginosus, which catalyzes the alpha,beta-elimination of L-cysteine to hydrogen sulfide, pyruvate, and ammonia. The production of pyruvate is measured
Clare Abbenhardt et al.
The Journal of nutrition, 144(5), 714-721 (2014-03-22)
Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may also affect inflammatory processes. We investigated these interrelated pathways to understand their relation. The
Yu Jin Jeon et al.
Archives of pharmacal research, 37(7), 907-915 (2013-10-03)
We examine the effect of rosmarinic acid (RA) in chemical hypoxia-induced injury in rat hepatocytes. Cell viability was significantly decreased by cobalt chloride (CoCl2), a well-known hypoxia mimetic agent in a time- and dose- dependent manner. RA pretreatment before exposure
Jingjing Liu et al.
Chemical research in toxicology, 28(3), 394-400 (2014-10-18)
Carcinogenic formaldehyde is produced by endogenous protein oxidation and various exogenous sources. With formaldehyde being both ubiquitous in the ambient environment and one of the most common reactive carbonyls produced from endogenous metabolism, quantifying formaldehyde exposure is an essential step
Na Wang et al.
Cancer, 120(19), 2965-2979 (2014-06-06)
The telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T have been found in many malignancies, including in thyroid carcinomas. However, it is unclear how early these mutations occur in thyroid tumorigenesis. The study included primary tumors from 58 patients
Nour Mammari et al.
PloS one, 9(6), e98491-e98491 (2014-06-03)
The severity of toxoplasmic infection depends mainly on the immune status of the host, but also on the Toxoplasma gondii strains, which differ by their virulence profile. The relationship between the human host and T. gondii has not yet been
Koryn A Carver et al.
American journal of physiology. Cell physiology, 307(11), C989-C998 (2014-07-25)
Mammals have circadian variation in blood pressure, heart rate, vascular tone, thrombotic tendency, and cerebral blood flow (CBF). These changes may be in part orchestrated by circadian variation in clock gene expression within cells comprising the vasculature that modulate blood
Jin-Ting Zhang et al.
Oncology reports, 14(6), 1519-1522 (2005-11-08)
Particularly interesting new cysteine-histidine rich protein (PINCH), an adapter protein involved in integrin and growth factor signalling, is up-regulated in the stroma of colorectal, breast, prostate, lung and skin cancer. Strong stromal immunostaining for PINCH is an independent prognostic indicator
Tobias Piroth et al.
Cell transplantation, 23(8), 995-1007 (2013-05-03)
Restorative cell therapy concepts in neurodegenerative diseases are aimed at replacing lost neurons. Despite advances in research on pluripotent stem cells, fetal tissue from routine elective abortions is still regarded as the only safe cell source. Progenitor cells isolated from
Joanna Czarnecka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 822(1-2), 85-90 (2005-07-05)
New method of qualitative and quantitative analysis of nucleotides in human cerebrospinal fluid (CSF), based on the combination of extraction of purines and pyrimidines to the solid phase (SPE) and high-performance liquid chromatography (HPLC), was proposed. Use of SPE and
Peng Ye et al.
Molecular and cellular biology, 34(18), 3421-3434 (2014-07-09)
The ubiquitin-proteasome pathway degrades ubiquitinated proteins to remove damaged or misfolded protein and thus plays an important role in the maintenance of many important cellular processes. Because the pathway is also crucial for tumor cell growth and survival, proteasome inhibition
Luc A Cynober
Nutrition (Burbank, Los Angeles County, Calif.), 18(9), 761-766 (2002-09-26)
The plasma concentration of an amino acid (AA) is the result of its rates of appearance (Ra) in and disappearance (Rd) from plasma. As for most nutrients, AA Ra and Rd are tightly regulated and at the postabsorptive state Ra
Rebecca Lamb et al.
Oncotarget, 6(7), 4585-4601 (2015-02-12)
We have used an unbiased proteomic profiling strategy to identify new potential therapeutic targets in tumor-initiating cells (TICs), a.k.a., cancer stem cells (CSCs). Towards this end, the proteomes of mammospheres from two breast cancer cell lines were directly compared to
Matthias Fellner et al.
Analytical biochemistry, 459, 56-60 (2014-05-27)
A fast and easy method for enzyme activity assays using the chromogenic Ellman reagent, 5,5'-dithiobis(2-nitrobenzoic acid), was developed. The method was used to measure the activity of the nonheme mono-iron enzyme cysteine dioxygenase. Quantifying the depletion of the substrate, cysteine
[Targeted effect profile - proven effectiveness].
MMW Fortschritte der Medizin, 155(5), 70-71 (2013-05-10)
Jason S McLellan et al.
Science (New York, N.Y.), 342(6158), 592-598 (2013-11-02)
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5 years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable
Anna Wonnerth et al.
Metabolism: clinical and experimental, 63(5), 647-653 (2014-03-19)
Interleukin-6 (IL-6) is a key cytokine in inflammatory diseases. It exerts its biological function via binding to a homodimer of its signal transducer glycoprotein 130 (gp130). Soluble gp130 (sgp130) is the natural inhibitor of IL-6 trans-signalling. The aim of this
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