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Juan D Unciti-Broceta et al.
The Journal of biological chemistry, 288(15), 10548-10557 (2013-02-28)
Nicotinamide, a soluble compound of the vitamin B3 group, has antimicrobial activity against several microorganisms ranging from viruses to parasite protozoans. However, the mode of action of this antimicrobial activity is unknown. Here, we investigate the trypanocidal activity of nicotinamide
Zhou Wu et al.
Neurobiology of aging, 34(12), 2715-2725 (2013-07-09)
Although chromogranin A (CGA) is frequently present in Alzheimer's disease (AD), senile plaques associated with microglial activation, little is known about basic difference between CGA and fibrillar amyloid-β (fAβ) as neuroinflammatory factors. Here we have compared the interleukin-1β (IL-1β) production
Aleksandra Glogowska et al.
The Journal of pathology, 231(4), 466-479 (2013-09-10)
We report a novel ligand-receptor system composed of the leucine-rich G-protein-coupled relaxin receptor, RXFP1, and the C1q-tumour necrosis factor-related protein 8 (CTRP8) in human primary brain cancer, a tumour entity devoid of the classical RXFP1 ligands, RLN1-3. In structural homology
Yan-Jun Zhong et al.
Oncology reports, 30(4), 1681-1686 (2013-07-24)
Ac‑Phe‑Lys‑PABC‑DOX (PDOX) is a smart doxorubicin (DOX) prodrug designed to decrease toxicities while maintaining the potent anticancer effects of DOX. The present study aimed to elucidate the molecular mechanisms of action of PDOX using MGC‑803 gastric cancer cells as a
The refined 2.15 AX-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.
Musil DJ, et al.
The Embo Journal, 10(9), 2321-2330 (1991)
Zhicheng Dou et al.
The Journal of biological chemistry, 288(5), 3523-3534 (2012-12-20)
Proteases regulate key events during infection by the pervasive intracellular parasite Toxoplasma gondii. Understanding how parasite proteases mature from an inactive zymogen to an active enzyme is expected to inform new strategies for blocking their actions. Herein, we show that
Biochemistry. How to solve protein structures with an X-ray laser.
John R Helliwell
Science (New York, N.Y.), 339(6116), 146-147 (2013-01-12)
Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis
Gu J, et al.
Cancer Prevention Research (Philadelphia, Pa.), 3(9), 1176-1186 (2010)
Hye-Rim Lee et al.
Toxicology, 304, 13-20 (2012-12-12)
Endocrine disrupting chemicals (EDCs) are defined as environmental compounds that modulate steroid hormone receptor-dependent responses an abnormal manner, resulting in adverse health problems for humans such as cancer growth and metastasis. Cathepsins are proteases that have been implicated in cancer
Sujatha Venkataraman et al.
The Journal of biological chemistry, 288(3), 1918-1928 (2012-12-06)
Aberrant expression of microRNAs has been implicated in many cancers. We recently demonstrated differential expression of several microRNAs in medulloblastoma. In this study, the regulation and function of microRNA 218 (miR-218), which is significantly underexpressed in medulloblastoma, was evaluated. Re-expression
Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts
Roberg K, et al.
The American Journal of Pathology, 161(1), 89-96 (2002)
Raymond F Hamilton et al.
Inhalation toxicology, 24(14), 995-1008 (2012-12-12)
Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in
Amino acid sequence of human liver cathepsin B
Ritonja A, et al.
Febs Letters, 181(1), 169-172 (1985)
Samy A F Morad et al.
Biochimica et biophysica acta, 1831(12), 1657-1664 (2013-08-14)
Acid ceramidase (AC), EC, a lysosomal enzyme, catalyzes the hydrolysis of ceramide to constituent sphingoid base, sphingosine, and fatty acid. Because AC regulates the levels of pro-apoptotic ceramide and mitogenic sphingosine-1-phosphate, it is considered an apt target in cancer
Shali Li et al.
The Journal of biological chemistry, 288(42), 30094-30104 (2013-08-30)
Impairment of glucose-stimulated insulin secretion caused by the lipotoxicity of palmitate was found in β-cells. Recent studies have indicated that defects in autophagy contribute to pathogenesis in type 2 diabetes. Here, we report that autophagy-related 7 (Atg7) induced excessive autophagic
Izidor Sosič et al.
Journal of medicinal chemistry, 56(2), 521-533 (2012-12-21)
Human cathepsin B has many house-keeping functions, such as protein turnover in lysosomes. However, dysregulation of its activity is associated with numerous diseases, including cancers. We present here the structure-based design and synthesis of new cathepsin B inhibitors using the
Bong Geom Jang et al.
PloS one, 8(10), e76466-e76466 (2013-10-15)
Hypoglycemia-induced brain injury is a common and serious complication of intensive insulin therapy experienced by Type 1 diabetic patients. We previously reported that hypoglycemic neuronal death is triggered by glucose reperfusion after hypoglycemia rather than as a simple result of
Leice M R de Novais et al.
Fitoterapia, 132, 26-29 (2018-08-17)
A new flavone, 4'-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by
C Marques et al.
Cell death & disease, 4, e507-e507 (2013-02-23)
Colorectal carcinoma (CRC) is one of the most common causes of cancer-related mortality. Short-chain fatty acids secreted by dietary propionibacteria from the intestine, such as acetate, induce apoptosis in CRC cells and may therefore be relevant in CRC prevention and
ChuanYun Dai et al.
Science China. Life sciences, 56(1), 51-58 (2013-01-15)
To design a releasable PEGylated TNF-α (rPEG-TNF-α), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF-α (PEG-TNF-α), facilitating its clinical use for anti-tumor therapy. Comparative pharmacokinetic and pharmacodynamic studies showed that the half-lives of both PEGylated forms
Arvind Dev et al.
The Journal of experimental medicine, 210(2), 225-232 (2013-01-16)
Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for red blood cell production and exert important cytoprotective effects on select vascular, immune, and cancer cells. To discover novel EPO action modes, we profiled the transcriptome of primary erythroid
Sreelatha Gopinath et al.
Carcinogenesis, 34(3), 550-559 (2012-12-12)
Cancer-initiating cells comprise a heterogeneous population of undifferentiated cells with the capacity for self-renewal and high proliferative potential. We investigated the role of uPAR and cathepsin B in the maintenance of stem cell nature in glioma-initiating cells (GICs). Simultaneous knockdown
Osvaldo Martinez et al.
Journal of virology, 87(7), 3801-3814 (2013-01-25)
Antigen-presenting cells (APCs) are critical targets of Ebola virus (EBOV) infection in vivo. However, the susceptibility of monocytes to infection is controversial. Studies indicate productive monocyte infection, and yet monocytes are also reported to be resistant to EBOV GP-mediated entry.
J S Bond et al.
The Biochemical journal, 189(1), 17-25 (1980-07-01)
The mechanism of degradation of fructose-1,6-bisphosphate aldolase from rabbit muscle by the lysosomal proteinase cathepsin B was determined. Treatment of aldolase with cathepsin B destroys up to 90% of activity with fructose 1,6-bisphosphate as substrate, but activity with fructose 1-phosphate
Rebekka Kubisch et al.
International journal of cancer, 134(10), 2478-2488 (2013-10-30)
The myxobacterial agent archazolid inhibits the vacuolar proton pump V-ATPase. V-ATPases are ubiquitously expressed ATP-dependent proton pumps, which are known to regulate the pH in endomembrane systems and thus play a crucial role in endo- and exocytotic processes of the
C Sato et al.
Journal of dental research, 92(2), 187-192 (2012-12-18)
Hydrogen peroxide is an oxidative agent commonly used for dental bleaching procedures. The structural and biochemical responses of enamel, dentin, and pulp tissues to the in vivo bleaching of human (n = 20) premolars were investigated in this study. Atomic
Ngasaman Ruttayaporn et al.
The Japanese journal of veterinary research, 61(4), 137-147 (2014-01-11)
Digestive enzymes in tsetse fly midgut are thought to modulate the development of African trypanosome which is a causative agent of trypanosomosis in human and animal. Cathepsin B is induced after the first blood meal ingestion and being higher in
Jin Na Shin et al.
The Journal of biological chemistry, 288(50), 35886-35895 (2013-11-02)
The association between altered proteostasis and inflammatory disorders has been increasingly recognized, but the underlying mechanisms are not well understood. In this study, we show that deficiency of either autophagy or sequestosome 1 (p62 or SQSTM) led to inflammasome hyperactivation
Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways
Wu X, et al.
Hepatology, 47(6), 1905-1915 (2008)
Yunjeong Kim et al.
Antiviral research, 97(2), 161-168 (2012-12-12)
Feline coronavirus infection is common among domestic and exotic felid species and usually associated with mild or asymptomatic enteritis; however, feline infectious peritonitis (FIP) is a fatal disease of cats that is caused by systemic infection with a feline infectious
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