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Natural Amino Acid Building Blocks for Peptide Synthesis
With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.
Crystallization
The elucidation of a macromolecular structure to the atomic level by X-ray or neutron diffraction analysis requires the molecule to be available in the form of relatively large single crystals. Many soluble proteins, membrane proteins, nucleic acids and nucleoprotein complexes...
Molecular Sieves
Molecular sieves are crystalline metal aluminosilicates having a threedimensional interconnecting network of silica and alumina tetrahedra. Natural water of hydration is removed from this network by heating to produce uniform cavities which selectively adsorb molecules of a specific size.
Microreactor Technology
Within the past two decades, Microreactor Technology (MRT) has evolved from a highly advanced toy for chemical engineers to a versatile tool for chemical synthesis. Since the time of the founders of synthetic chemistry, like Justus von Liebig or Friedrich...
SyTracks Carbon Monoxide Generator FAQs
What is COgen? What is COware? What is the SyTracks COgenerator system? And more questions answered.
Greener Methods: Catalytic Amide Bond Formation
We are proud to offer a number of products used in catalytic amidation technology.
Facile and Rapid Chiral Resolution with ChiroSolv Kits
Our company is pleased to partner with ChiroSolve, Inc. to offer, through an exclusive distribution agreement, a series of ready-to-use kits for chiral resolution of racemates.
Scavengers
Functionalized Silica Gels
Organosilanes for Cross-coupling
Over the past several years, Pd-catalyzed cross-coupling of silicon compounds has rapidly gained acceptance as a suitable alternative to more commonly known methods such as: Stille (Sn), Kumada (Mg), Suzuki (B), and Negishi (Zn) cross-couplings.
Selective Metalations
Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl
Aldehydes
Aldehydes are perennially attractive building blocks due to their ability to easily react with many nucleophiles.
Fluoroalkylation: Expansion of Togni Reagents
The fluoroalkylation toolbox now includes Togni reagents, hypervalent iodine perfluoroalkylation reagents, fluoroalkyl bromides, silanes, carboxylates, and sulfonyl fluorides for late stage fluoroalkylation.
Sodium Triacetoxyborohydride
Sodium triacetoxyborohydride
Glycol Ethers
Glycol ethers, with both an ether and alcohol functional group in the same molecule, are one of the most versatile classes of organic solvents.
Organic Azides and Azide Sources
Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.
Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)
This technical article discusses Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®).
(+)-Sparteine Surrogate
Sigma-Aldrich.com presents an article concerning (+)-Sparteine Surrogate.
Solvent Stabilizer Systems
A description of stabilizer systems for solvents including esters, ethyl ester, tetrahydrofuran, chlorinated solvents, chloroform and dichloromethane.
Application of Carbon Monoxide in Synthesis Made Simple and Safe by Prof. Skrydstrup and Coworkers
Studies in the field of carbonylation chemistry led to the discovery of a novel carbon monoxide (CO) delivery system.
LAB Reagents
Lithium aminoborohydride (LAB) reagents are a new class of powerful and selective reagents developed in the laboratory of Professor Bakthan Singaram at the University of California, Santa Cruz.
Traditional Strong and Hindered Bases
Traditional-Strong-and-Hindered-Bases
Red-Al® Reducing Agent
Red-Al®, or sodium bis(2-methoxyethoxy)aluminum dihydride (Vitride®, SMEAH), is a versatile reducing agent and a good substitute for LiAlH4 in many reactions. Red-Al® is nonpyrophoric, although still moisture-sensitive, and is available in solution, allowing for easier handling compared to LiAlH4.
Inverse Electron Demand Diels–Alder Reactions of 1,2,4,5-Tetrazines and 1,2,3-Triazines
The inverse electron demand Diels-Alder reactions of electron-deficient heterocycles are significant cycloaddition reactions for the total synthesis of natural products containing highly substituted and functionalized heteroaromatic ring systems.
Asymmetric Hydrogenation
Asymmetric hydrogenation plays an important role in today’s synthesis world. Knowles and Noyori pioneered this field and were rewarded with the Nobel Prize in 2001 for their work.
Mild Mg – Halogen Exchange
Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.
CBILS©
The use of CBILS© – Carbonate Based Ionic Liquid Synthesis – developed by the Austrian company proionic, offers one of the simplest, yet most elegant synthetic methods for the production of ionic liquids
JandaJels™
JandaJels are designed to create a “solvent-like organic microenvironment to catalyze organic reactions”. The flexible tetrahydrofuran-like cross-linker gives the JandaJels increased swelling and solvation characteristics as compared to polystyrene resins cross-linked with divinylbenzene.
Alkali Metal Silica Gels from SiGNa
SiGNa Chemistry has recently developed a technology for encapsulating alkali metals into nano-structured porous oxides to create stable, free flowing powders with varying reactivities (based on the intended application).
Dietary Terpenes
Terpenes comprise the largest and most diverse class of secondary metabolites; approximately 55,000 compounds have been identified to date.
Imidazolium Derived Reagents
N-Acylimidazoles were recognized in the early 1950s as reactive intermediates suitable for the acylation of amino compounds. The search for better coupling reagents than DCC led to the development of CDI (1,1’-carbonyldiimidazole) and related carbonylimidazoles.
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