hpa017293

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Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

Frank H Yu et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(20), 7577-7585 (2003-08-22)

The principal alpha subunit of voltage-gated sodium channels is associated with auxiliary beta subunits that modify channel function and mediate protein-protein interactions. We have identified a new beta subunit termed beta4. Like the beta1-beta3 subunits, beta4 contains a cleaved signal

Crystallographic insights into sodium-channel modulation by the β4 subunit.

John Gilchrist et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(51), E5016-E5024 (2013-12-04)

Voltage-gated sodium (Nav) channels are embedded in a multicomponent membrane signaling complex that plays a crucial role in cellular excitability. Although the mechanism remains unclear, β-subunits modify Nav channel function and cause debilitating disorders when mutated. While investigating whether β-subunits

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer.

Emeline Bon et al.

Nature communications, 7, 13648-13648 (2016-12-06)

The development of metastases largely relies on the capacity of cancer cells to invade extracellular matrices (ECM) using two invasion modes termed 'mesenchymal' and 'amoeboid', with possible transitions between these modes. Here we show that the SCN4B gene, encoding for

SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.

Argelia Medeiros-Domingo et al.

Circulation, 116(2), 134-142 (2007-06-27)

Congenital long-QT syndrome (LQTS) is potentially lethal secondary to malignant ventricular arrhythmias and is caused predominantly by mutations in genes that encode cardiac ion channels. Nearly 25% of patients remain without a genetic diagnosis, and genes that encode cardiac channel

The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells.

Adélaïde Doray et al.

Cells, 10(7) (2021-07-03)

The SCN4B gene, coding for the NaVβ4 subunit of voltage-gated sodium channels, was recently found to be expressed in normal epithelial cells and down-regulated in several cancers. However, its function in normal epithelial cells has not been characterized. In this

Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation.

Ruo-Gu Li et al.

International journal of molecular medicine, 32(1), 144-150 (2013-04-23)

Atrial fibrillation (AF) represents the most common form of sustained cardiac arrhythmia and accounts for substantial morbidity and mortality. Mutations in the cardiac sodium channel α, β1, β2 and β3 subunit genes (SCN5A, SCN1B, SCN2B and SCN3B) have been associated

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