- The synthesis of low molecular weight pyrrolo[2,3-c]pyridine-7-one scaffold.
The synthesis of low molecular weight pyrrolo[2,3-c]pyridine-7-one scaffold.
Molecular diversity (2012-10-31)
Maxim A Nechayev, Nikolay Yu Gorobets, Alexander V Borisov, Sergiy M Kovalenko, Andrey A Tolmachev
PMID23108947
ABSTRACT
A facile method for the synthesis of substituted pyrrolo[2,3-c]pyridine-7-ones is developed that applies an acid-promoted intramolecular cyclization of 2-pyrrolecarboxylic acid amidoacetals as key step. The synthesis is easily scaled up to 1.5 mol quantity with no yield decrease. The alkylation/arylation reaction of the pyrrolo[2,3-c]pyridine-7-ones proceeds regioselectively giving N6-substituted derivatives.
MATERIALS