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Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke.

Brain research (2003-09-12)
J G Pilitsis, W M Coplin, M H O'Regan, J M Wellwood, F G Diaz, M R Fairfax, D B Michael, J W Phillis
ABSTRACT

Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) from patients with ischemic and hemorrhagic stroke (n=25) and in contemporary controls (n=73) were examined using HPLC. Concentrations of CSF FFAs from ischemic and hemorrhagic stroke patients obtained within 48 h of the insult were significantly greater than in control patients. Higher concentrations of polyunsaturated fatty acids (PUFAs) in CSF obtained within 48 h of insult were associated with significantly lower (P<0.05) admission Glasgow Coma Scale scores and worse outcome at the time of hospital discharge, using the Glasgow Outcome Scale (P<0.01).

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