Merck

Synthesis of [2H7]indatraline.

Journal of labelled compounds & radiopharmaceuticals (2014-11-11)
L Allmendinger, K T Wanner
ABSTRACT

Deuterium-labelled indatraline was synthesized in high efficiency employing a Friedel-Crafts alkylation of [(2)H6]benzene with (E)-3-(3,4-dichlorophenyl)acrylic acid as a key step. The desired labelling of the final compound was ascertained in two ways, by incorporation of [(2)H6]benzene in the target molecule and additionally by deuterium transfer to the non-deuterated aryl moiety of the Friedel-Crafts alkylation product from [(2)H6]benzene, the latter thus serving as reagent and solvent.

MATERIALS
Product Number
Brand
Product Description

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