CEP57
centrosomal protein 57kDa
Sinónimos:
MVA2, PIG8, TSP57
Especie:
Human CEP57 (9702), Mouse Cep57 (74360), Rat Cep57 (315423), cow CEP57 (353245), sheep CEP57 (101102008), domestic guinea pig Cep57 (100714775), naked mole-rat Cep57 (101715850), chicken CEP57 (418993), Zebrafish cep57 (791201), dog CEP57 (476766)
ID UniProtKB:
ID del gen:
- Human(9702) Summary: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
- Mouse(74360) centrosomal protein 57
- Rat(315423) centrosomal protein 57
- cow(353245) centrosomal protein 57kDa
- sheep(101102008) centrosomal protein 57kDa
- domestic guinea pig(100714775) centrosomal protein 57kDa
- naked mole-rat(101715850) centrosomal protein 57kDa
- chicken(418993) centrosomal protein 57kDa
- Zebrafish(791201) centrosomal protein 57
- dog(476766) centrosomal protein 57kDa
- domestic cat(101084902) centrosomal protein 57kDa
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-CEP57 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Cep57 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-CEP57 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
immunofluorescence
western blot
western blot