GCH1
GTP cyclohydrolase 1
Sinónimos:
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
Especie:
Human GCH1 (2643), Mouse Gch1 (14528), Rat Gch1 (29244), Zebrafish gch1 (100192219), sheep GCH1 (101112987), domestic guinea pig Gch1 (100735198), naked mole-rat Gch1 (101706667), Domestic Rabbit GCH1 (100286831), cow GCH1 (286815), sheep GCH1 (100303455) ...Más
ID UniProtKB:
ID del gen:
- Human(2643) Summary: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]
- Mouse(14528) GTP cyclohydrolase 1
- Rat(29244) GTP cyclohydrolase 1
- Zebrafish(100192219) GTP cyclohydrolase 1
- sheep(101112987) GTP cyclohydrolase 1
- domestic guinea pig(100735198) GTP cyclohydrolase 1
- naked mole-rat(101706667) GTP cyclohydrolase 1
- Domestic Rabbit(100286831) GTP cyclohydrolase 1
- cow(286815) GTP cyclohydrolase 1
- sheep(100303455) GTP cyclohydrolase 1
- dog(609393) GTP cyclohydrolase 1
- domestic cat(101092120) GTP cyclohydrolase 1
- chicken(396146) GTP cyclohydrolase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-GCH1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-GCH1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
Anti-GCH1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
immunohistochemistry