PTEN
phosphatase and tensin homolog
Sinónimos:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Especie:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), naked mole-rat Pten (101714930), domestic guinea pig Pten (100723659), sheep PTEN (101119351), cow PTEN (540786), domestic cat PTEN (101091813), dog PTEN (403832)
ID UniProtKB:
ID del gen:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- naked mole-rat(101714930) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-PTEN Antibody, clone 6H2.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP218, affinity isolated antibody,
Reactividad de especies
dog, frog, human, mouse
Aplicación
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM265, purified immunoglobulin,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti- PTEN antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-PTEN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
canine, human, mouse, rat
Aplicación
ELISA
western blot
western blot