802298

Sigma-Aldrich

Buchwald-Hartwig Amination in a Box

greener alternative
NACRES:
NA.22

Nivel de calidad

100

características de los productos alternativos más sostenibles

Waste Prevention
Safer Solvents and Auxiliaries
Design for Energy Efficiency
Catalysis
Learn more about the Principles of Green Chemistry.

categoría alternativa más sostenible

Aligned

temp. de almacenamiento

2-8°C

Aplicación

This second-generation kit contains the reagents, catalyst, and solvent required to perform a Buchwald-Hartwig reaction in TPGS-750-M, a surfactant developed by the Lipshutz group as a greener alternative to organic solvents. This technology allows common metal-catalyzed reactions to be run under aqueous conditions, considerably reducing solvent waste. The components are pre-weighed in the appropriate amounts for a 0.5mmol scale reaction.

Please refer to the attached
Protocol for details.

pictogramas

FlameCorrosion

Palabra de señalización

Danger

Frases de peligro

Riesgos supl.

EUH014

RIDADR

UN 3316 9

Certificado de Análisis
Bruce H Lipshutz et al.
The Journal of organic chemistry, 76(11), 4379-4391 (2011-05-10)
An environmentally benign surfactant (TPGS-750-M), a diester composed of racemic α-tocopherol, MPEG-750, and succinic acid, has been designed and readily prepared as an effective nanomicelle-forming species for general use in metal-catalyzed cross-coupling reactions in water. Several "name" reactions, including Heck...
Bruce H Lipshutz et al.
Angewandte Chemie (International ed. in English), 52(42), 10952-10958 (2013-09-14)
Transition-metal-catalyzed carbon-carbon and carbon-heteroatom bond formations are among the most heavily used types of reactions in both academic and industrial settings. As important as these are to the synthetic community, such cross-couplings come with a heavy price to our environment...
Artículos
Reactions once dependent on organic solvents are now being performed in water to eliminate the contributions of organic solvents to chemical waste – and the methodology just became easier with next-generation designer surfactant kits.
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Contenido relacionado
Prof. Bruce Lipshutz and co-workers have developed designer surfactants to allow several classes of transformations (e.g. Suzuki-Miyaura, Olefin Metathesis, 1,4-Addition to Enones, etc.) to be performed in water.
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