D125407

Sigma-Aldrich

DIC

99%

Sinónimos:
N,N′-Diisopropylcarbodiimide
Fórmula lineal:
(CH3)2CHN=C=NCH(CH3)2
Número de CAS:
Peso molecular:
126.20
Beilstein/REAXYS Number:
878281
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.22

Nivel de calidad

200

ensayo

99%

reaction suitability

reaction type: Coupling Reactions

aplicaciones

peptide synthesis: suitable

índice de refracción

n20/D 1.433 (lit.)

bp

145-148 °C (lit.)

densidad

0.815 g/mL at 20 °C (lit.)

SMILES string

CC(C)N=C=NC(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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Descripción general

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Aplicación

DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Coupling reagent for peptide syntheses.
Alternative to dicyclohexylcarbodiimide in peptide synthesis.

Envase

5, 25, 100, 500 g in glass bottle
1 kg in glass bottle
10 kg in poly drum

Palabra de señalización

Danger

hazcat

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

storage_class_code

3 - Flammable liquids

WGK Alemania

WGK 3

Punto de inflamabilidad F

91.4 °F

Punto de inflamabilidad C

33 °C

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificado de Análisis

Certificado de origen

Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic...
Synthesis of 2-oxazolines mediated by N,N'-diisopropylcarbodiimide.
Crosignani S, et al.
Tetrahedron Letters, 45(52), 9611-9615 (2004)
Tetrahedron Letters, 35, 5981-5981 (1994)
Anupam Patgiri et al.
Nature protocols, 5(11), 1857-1865 (2010-10-30)
Stabilized α-helices and nonpeptidic helix mimetics have emerged as powerful molecular scaffolds for the discovery of protein-protein interaction inhibitors. Protein-protein interactions often involve large contact areas, which are often difficult for small molecules to target with high specificity. The hypothesis...
Artículos
Amide bonds are ubiquitous in both nature and industrial applications. They are vital to the structure and function of biological macromolecules and polymers. The importance of this functionality has resulted in numerous approaches to its formation, ranging from stoichiometric activation of carboxylic acids to more recent advances in catalytic amide bond formation.
Más información

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