850311C

Avanti

DOCP

2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate, chloroform

Empirical Formula (Hill Notation):
C43H82NO8P
Número de CAS:
Peso molecular:
772.09
NACRES:
NA.25

ensayo

>99% (TLC)

envase

pkg of 1 × 2.5 mL (850311C-25mg)
pkg of 2 × 4 mL (850311C-200mg)

manufacturer/tradename

Avanti Polar Lipids 850311C

concentración

10 mg/mL (850311C-25mg)
25 mg/mL (850311C-200mg)

enviado en

dry ice

temp. de almacenamiento

−20°C

Descripción general

Inverse-phosphocholine lipids, a remix of a common phospholipid, contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Therefore iPC lipids afford a unique opportunity to investigate the biophysical and bioactivity-related ramifications of a charge inversion at the bilayer surface.
DOCP is a zwitterionic /negatively charged lipid. It possess an inverse headgroup This synthetic molecule has stronger affinity than 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS).

Aplicación

DOCP is suitable for use in the preparation of large unilamellar vesicles (LUVs) and in the preparation of liposomes.

Envase

5 mL Clear Glass Sealed Ampule (850311C-25mg)
5 mL Clear Glass Sealed Ampule (850311C-200mg)

pictogramas

Skull and crossbonesHealth hazard

Palabra de señalización

Danger

Órganos de actuación

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Alemania

WGK 3

Punto de inflamabilidad F

does not flash

Punto de inflamabilidad C

does not flash

Partition of Positively and Negatively Charged Tryptophan Ions in Membranes with Inverted Phospholipid Heads: Simulations and Experiments
Cardenas AE, et al.
The Journal of Physical Chemistry B (2019)
A Stable Lipid/TiO2 Interface with headgroup-inversed phosphocholine and a comparison with SiO2
Wang F and Liu J
Journal of the American Chemical Society, 137(36), 11736-11742 (2015)
Charge and Coordination Directed Liposome Fusion onto SiO2 and TiO2 Nanoparticles
Wang X, et al.
Langmuir, 35(5), 1672-1681 (2018)
Inorganic cadmium affects the fluidity and size of phospholipid based liposomes
Kerek EM and Prenner EJ
Biochimica et Biophysica Acta - Biomembranes, 1858(12), 3169-3181 (2016)
Yibo Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 34(32), 9337-9348 (2018-03-13)
Phospholipids are a major component of the cell membrane. In most natural phospholipids, the phosphate acts as a bridge, connecting the other portion of the polar headgroup with the hydrophobic tails. Such bridging phosphate is chemically quite inert. Synthetic lipids...

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