Merck
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04-959

Sigma-Aldrich

Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2

clone RORg2, from hamster(Armenian)

Synonym(s):
RAR-related orphan receptor C, RAR-related orphan receptor gamma, retinoic acid-binding receptor gamma, nuclear receptor ROR-gamma, retinoid-related orphan receptor gamma, Nuclear receptor RZR-gamma, RZR-GAMMA, Nuclear receptor subfamily 1 group F member
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

hamster (Armenian)

Nivel de calidad

100

forma del anticuerpo

purified antibody

antibody product type

primary antibodies

clon

RORg2, monoclonal

species reactivity

mouse

technique(s)

western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

Gene Information

mouse ... Rorc(19885)

Descripción general

Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.

Inmunógeno

Epitope: Unknown
Histidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT).

Aplicación

Research Sub Category
Inflammation & Autoimmune Mechanisms
Detect Retinoid-Related Orphan Receptor γ T using this Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 validated for use in WB, FC & IF.
Research Category
Inflammation & Immunology

Calidad

Evaluated by Western Blot in EL4 cell lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate.

Descripción de destino

~52 kDa observed

Forma física

Protein G Purified
Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
EL4 cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

12 - Non Combustible Liquids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Quality

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