Tuning microtubule-based transport through filamentous MAPs: the problem of dynein.
Michael Vershinin, Jing Xu, David S Razafsky, Stephen J King, Steven P Gross
Malin H Stridh et al.
The Journal of physiology, 590(10), 2333-2351 (2012-03-28)
Rapid exchange of metabolites between different cell types is crucial for energy homeostasis of the brain. Besides glucose, lactate is a major metabolite in the brain and is primarily produced in astrocytes. In the present study, we report that carbonic...
Sina Ibne Noor et al.
The Journal of biological chemistry, 290(7), 4476-4486 (2015-01-07)
Proton-coupled monocarboxylate transporters (MCTs) mediate the exchange of high energy metabolites like lactate between different cells and tissues. We have reported previously that carbonic anhydrase II augments transport activity of MCT1 and MCT4 by a noncatalytic mechanism, while leaving transport...
Katrina Montales et al.
Scientific reports, 11(1), 467-467 (2021-01-13)
The protein kinase ATR is activated at sites of DNA double-strand breaks where it plays important roles in promoting DNA end resection and regulating cell cycle progression. TOPBP1 is a multi BRCT repeat containing protein that activates ATR at DSBs....
Linda S Forero-Quintero et al.
The Journal of biological chemistry, 294(2), 593-607 (2018-11-18)
Monocarboxylate transporters (MCTs) mediate the proton-coupled exchange of high-energy metabolites, including lactate and pyruvate, between cells and tissues. The transport activity of MCT1, MCT2, and MCT4 can be facilitated by the extracellular carbonic anhydrase IV (CAIV) via a noncatalytic mechanism....