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05-824

Sigma-Aldrich

Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal

clone 68-4, Upstate®, from rabbit

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25 μL
151,00 €
100 μL
449,00 €

About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

151,00 €


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origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

68-4, monoclonal

reactividad de especies

human

envase

antibody small pack of 25 μL

fabricante / nombre comercial

Upstate®

técnicas

immunoprecipitation (IP): suitable
western blot: suitable

isotipo

IgG

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

ambient

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ESR2(2100)

Descripción general

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
Produced in collaboration with Epitomics

Especificidad

Predicted to cross-react with rat and mouse based on sequence homology
Recognizes Estrogen Receptor β, long form, does not detect estrogen receptor alpha.

Inmunógeno

KLH-conjugated linear peptide corresponding to amino acids 108-127 from the N-terminal half of human estrogen receptor beta.

Aplicación

Detect Estrogen Receptor β also known as Nuclear receptor subfamily 3 group A member 2 with Anti-Estrogen Receptor β Antibody, clone 68-4 (Rabbit Monoclonal Antibody), that has been demonstrated to work in IP & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Calidad

routinely evaluated by immunoblot on RIPA lysates from MCF7 cells

Descripción de destino

59 kDa

Forma física

Format: Purified
Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% sodium azide, pH 7.4.
Protein A purified

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
MCF7 cell extracts

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Up-regulation of estrogen receptor-beta expression during osteogenic differentiation of human periodontal ligament cells.
X Tang, H Meng, J Han, L Zhang, J Hou, F Zhang
Journal of Periodontal Research null
Estrogen and cytochrome P450 1B1 contribute to both early- and late-stage head and neck carcinogenesis.
Shatalova, EG; Klein-Szanto, AJ; Devarajan, K; Cukierman, E; Clapper, ML
Cancer Prevention Research (Philadelphia, Pa.) null
Iad Alhallak et al.
Reproductive sciences (Thousand Oaks, Calif.), 30(8), 2429-2438 (2023-02-15)
Endometriosis (ENDO) is a chronic estrogen-dependent gynecological condition that affects reproductive-age women, causing pelvic pain, infertility, and increased risk for ovarian cancer. Diabetes mellitus (DM) is a metabolic disease with significant morbidity and mortality and rising incidence worldwide. The occurrence
Guangfeng Zhang et al.
Molecular endocrinology (Baltimore, Md.), 24(9), 1737-1747 (2010-07-28)
Recent studies have demonstrated the presence of estrogen receptor (ER)beta in the mitochondria in various cell types and tissues, but the exact function of this localization remains unclear. In this study, we have examined the function of mitochondrial ERbeta in
M A Karim Rumi et al.
Endocrinology, 158(7), 2330-2343 (2017-05-19)
Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females.

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