Saltar al contenido
Merck
Todas las fotos(1)

Documentos

06-900

Sigma-Aldrich

Anti-SynGAP Antibody

Upstate®, from rabbit

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

purified antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

reactividad de especies

rat

fabricante / nombre comercial

Upstate®

técnicas

immunocytochemistry: suitable
western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

dry ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... SYNGAP1(8831)

Descripción general

Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

Especificidad

SynGAP

Inmunógeno

peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a

Aplicación

Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

Ligadura / enlace

Replaces: 04-1071

Forma física

Format: Purified
Protein A purified
Purified in PBS with 0.05% NaN3 and 30% Glycerol

Almacenamiento y estabilidad

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Información legal

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿Aún no puede encontrar el producto adecuado?  

Pruebe nuestra Herramienta de selección de productos.

Clase de riesgo para el agua (WGK)

WGK 2


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

SynGAP isoforms exert opposing effects on synaptic strength.
McMahon, AC; Barnett, MW; O'Leary, TS; Stoney, PN; Collins, MO; Papadia, S; Choudhary et al.
Nature Communications null
Ayse Dosemeci et al.
FEBS letters, 590(17), 2934-2939 (2016-08-02)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B, also known as AIDA-1) is a major component of the postsynaptic density (PSD) in excitatory neurons where it concentrates at the electron-dense core under basal conditions and moves out during
Characterization of a novel synGAP isoform, synGAP-beta.
Li, W; Okano, A; Tian, QB; Nakayama, K; Furihata, T; Nawa, H; Suzuki, T
The Journal of Biological Chemistry null
Cristin D Davidson et al.
Annals of clinical and translational neurology, 3(5), 366-380 (2016-05-28)
Niemann-Pick type C (NPC) disease is a fatal, neurodegenerative, lysosomal storage disorder characterized by intracellular accumulation of unesterified cholesterol (UC) and other lipids. While its mechanism of action remains unresolved, administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) has provided the greatest disease amelioration
Murat Kilinc et al.
eLife, 11 (2022-04-09)
Loss-of-function variants in SYNGAP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple cellular functions of SynGAP proteins through coding of distinct C-terminal motifs.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico