1.02735

L-Cysteine hydrochloride monohydrate

EMPROVE^® EXPERT, Ph. Eur., JP, USP

• Synonym(s): Cys, L-Cysteinium Chloride Monohydrate, L-Cysteine Hydrochloride, Monohydrate
• Linear Formula: HSCH₂CH(NH₂)COOH · HCl · H₂O
• CAS Number: 7048-04-6
• Molecular Weight: 175.63
• Beilstein: 5158059
• Número MDL: MFCD00065606
• Número índice de la CE: 200-157-7

Properties

• Agency: JP; Ph. Eur.; USP
• Nivel de calidad: 500
• presión de vapor: <0.1 hPa ( 20 °C)
• Línea del producto: EMPROVE^® EXPERT
• ensayo: 98.5-101.0% dry basis (alkalimetric)
• formulario: crystalline powder
• pH: 0.8-1.2 (20 °C, 100 g/L in H₂O)
• mp: 168-170 °C
• solubilidad: 650 g/L
• densidad: 1.54 g/cm³
• densidad aparente: 780 kg/m³
• trazas de anión: sulfate (SO₄^2-): ≤300 ppm
• trazas de catión: Fe: ≤20 ppm; heavy metals (as Pb): ≤10 ppm
• temp. de almacenamiento: 2-30°C
• SMILES string: O.Cl.N[C@@H](CS)C(O)=O
• InChI: 1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1
• InChI key: QIJRTFXNRTXDIP-JIZZDEOASA-N

Description

Envase

1 kg in PE bottle

3 kg in Fibre case

10 kg in Plastic drum

25 kg in PE drum

Acciones bioquímicas o fisiológicas

NMDA glutamatergic receptor antagonist.

Nota de análisis

Assay (alkalimetric, calculated on dried substance): 98.5 - 101.0 %
Identity (IR-spectrum): passes test
Identity (Chloride): passes test
Appearance: white to almost white crystalline powder or colorless crystals
Appearance of solution (25 g/l, water): clear and not more intense in color than reference solution BY₆
Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 250 g/l, calc. on dried substance): +5.5 to +7.0
Spec. rotation (α 25/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance): +5.7 to +6.8
Sulfate (SO₄): ≤ 300 ppm
Heavy metals (as Pb): ≤ 10 ppm
Fe (Iron): ≤ 20 ppm
Related Compounds, total (TLC): ≤ 0.5 %
Ninhydrin-positive substances (LC)(impurity A (570 nm)): ≤ 0.5 %
Ninhydrin-positive substances (LC)(any ninhydrin-positive impurity): ≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm)): ≤ 0.02 %
Ninhydrin-positive substances (LC)(total impurities): ≤ 1.0 %
Residual solvents (ICH Q3C): excluded by manufacturing proces
Sulfated ash (600 °C): ≤ 0.1 %
Loss on drying (Vacuum < 0.7 kPa, P₂O₅, 24 h): 8.0 - 12.0 %
Bacterial endotoxins: ≤ 6.0 I.U./g
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., USP.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 1
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable