Merck
All Photos(3)

1.04354

SAFC

L-Histidine monohydrochloride monohydrate

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP

Synonym(s):
His, L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride
Empirical Formula (Hill Notation):
C6H9N3O2 · HCl · H2O
CAS Number:
Molecular Weight:
209.63
Beilstein:
4168261
Número MDL:
Número índice de la CE:
211-438-9

Agency

BP
ChP
JP
Ph. Eur.

Nivel de calidad

500

presión de vapor

<1 hPa ( 20 °C)

Línea del producto

EMPROVE® EXPERT

ensayo

98.5-101.0% (alkalimetric)
99.0-101.0% (perchloric acid titration)

formulario

solid

pH

3.5-4.5 (20 °C, 100 g/L in H2O)

mp

254 °C (dec.) (lit.)

solubilidad

149.55 g/L

densidad

1.49 g/cm3 at 20 °C

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

temp. de almacenamiento

2-30°C

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Descripción general

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Histidine monohydrochloride is used in biopharmaceutical manufacturing as a buffer in formulation. It is often used along with histidine to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine monohydrochloride monohydrate Emprove® Expert is especially suitable for high-risk applications.

Envase

500 g in PE bottle
1.5 kg in PE bottle
10 kg in PE bag (in PE pail)

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

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