1.04354

L-Histidine monohydrochloride monohydrate

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP

• Synonym(s): His, L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride
• Empirical Formula (Hill Notation): C₆H₉N₃O₂ · HCl · H₂O
• CAS Number: 5934-29-2
• Molecular Weight: 209.63
• Beilstein: 4168261
• Número MDL: MFCD00151027
• Número índice de la CE: 211-438-9

Properties

• Agency: BP; ChP; JP; Ph. Eur.
• Nivel de calidad: 500
• presión de vapor: <1 hPa ( 20 °C)
• Línea del producto: EMPROVE^® EXPERT
• ensayo: 98.5-101.0% (alkalimetric); 99.0-101.0% (perchloric acid titration)
• formulario: solid
• pH: 3.5-4.5 (20 °C, 100 g/L in H₂O)
• mp: 254 °C (dec.) (lit.)
• solubilidad: 149.55 g/L
• densidad: 1.49 g/cm³ at 20 °C
• application(s): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• temp. de almacenamiento: 2-30°C
• SMILES string: O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O
• InChI: 1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
• InChI key: CMXXUDSWGMGYLZ-XRIGFGBMSA-N

Description

Descripción general

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Histidine monohydrochloride is used in biopharmaceutical manufacturing as a buffer in formulation. It is often used along with histidine to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine monohydrochloride monohydrate Emprove^® Expert is especially suitable for high-risk applications.

Envase

500 g in PE bottle

1.5 kg in PE bottle

10 kg in PE bag (in PE pail)

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 1
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable