1.08219

Tris(hydroxymethyl)aminomethane hydrochloride

EMPROVE^® EXPERT

• Synonym(s): Trizma^® hydrochloride, TRIS HCl, TRIS hydrochloride, Tris(hydroxymethyl)aminomethane hydrochloride, Tromethane hydrochloride
• Linear Formula: NH₂C(CH₂OH)₃ · HCl
• CAS Number: 1185-53-1
• Molecular Weight: 157.60
• Beilstein: 3675235
• Número MDL: MFCD00012590
• Número índice de la CE: 214-684-5

Properties

• presión de vapor: <1 Pa ( 50 °C)
• Nivel de calidad: 500
• Línea del producto: EMPROVE^® EXPERT
• formulario: solid
• pH: 4.2 (20 °C, 100 g/L in H₂O)
• useful pH range: 7.0-9.0
• pKa (25 °C): 8.1
• mp: 150.7 °C
• solubilidad: soluble 561 g/L
• densidad: 1.28 g/cm³ at 20.2 °C
• application(s): parenterals
• temp. de almacenamiento: 15-25°C
• SMILES string: Cl.NC(CO)(CO)CO
• InChI: 1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H
• InChI key: QKNYBSVHEMOAJP-UHFFFAOYSA-N

Description

Descripción general

Finding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

The pH values of all buffers are temperature and concentration dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution.
For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Envase

10 kg in Plastic drum

Otras notas

Due to its low microbial and endotoxin limits, Tris(hydroxymethyl)aminomethane hydrochloride Emprove^® Expert is suitable for biopharma manufacturing needs.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Trizma is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 1
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable