119137

Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride

• Synonym(s): Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride, CGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid
• Empirical Formula (Hill Notation): C₂₃H₂₉N₇O₆ · xHCl
• CAS Number: 124182-57-6
• Molecular Weight: 499.52 (free base basis)

Properties

• Análisis: ≥96% (HPLC)
• Nivel de calidad: 100
• formulario: solid
• manufacturer/tradename: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 100 mM
• enviado en: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22?/m0/s1
• InChI key: PAOANWZGLPPROA-OFRRTHGGSA-N

Description

Descripción general

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27 nM). Exhibits reduced affinity for A_2B receptors (K_i = 67 nM), but offers greater selectivity over A_1R (K_i = 290 nM) and A_3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease.

A xanthin derivative that acts as a potent agonist of adenosine A_2A receptors (K_i = 27 nM). Exhibits reduced affinity for A_2B receptors (K_i = 67 nM), but offers greater selectivity over A_1R (K_i = 290 nM) and A_3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington′s disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Forma física

Supplied as a hydrochloride salt.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Willians, A. J., et al. 2012. Inflammation.35, 614.
Mazzon, E. et al. 2011. J Rheumatol.38, 2119,
Martire, A., et al. 2007. Neurosci Lett.417, 78.
Chou, S. Y., et al, 2005. Journ Neurochem.93, 310.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
Phillis, J. W., et al. 1990.Brain Res.509, 328.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 2
• Punto de inflamabilidad C: Not applicable