Merck
  • 119139
All Photos(1)

119139

Sigma-Aldrich

Adenosine A3 Receptor Agonist, 2-Cl-IB-MECA

A highly selective agonist of adenosine A3 receptor (Ki = 330 pM)

All Photos(1)
Synonym(s):
Adenosine A3 Receptor Agonist, 2-Cl-IB-MECA
Empirical Formula (Hill Notation):
C18H18ClIN6O4
CAS Number:
163042-96-4
Molecular Weight:
544.73
Número MDL:
MFCD01861178

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

solid

manufacturer/tradename

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

white

solubilidad

DMSO: 20 mg/mL

enviado en

ambient

temp. de almacenamiento

−20°C

InChI

1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1

InChI key

IPSYPUKKXMNCNQ-PFHKOEEOSA-N

Descripción general

A highly selective agonist of adenosine A3 receptor (Ki = 330 pM)
An adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Kim, H. O., et al. 1994. J Med Chem.37, 3614.
Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83.
Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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