119149

Adenosine A2A Receptor Antagonist I, ZM 241385

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (K_i = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

• Synonym(s): Adenosine A2A Receptor Antagonist I, ZM 241385
• Empirical Formula (Hill Notation): C₁₆H₁₅N₇O₂
• CAS Number: 139180-30-6
• Molecular Weight: 337.34
• Número MDL: MFCD00908394

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• potencia: 800 pM K_i
• manufacturer/tradename: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 15 mg/mL
• application(s): air monitoring
• enviado en: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
• InChI key: PWTBZOIUWZOPFT-UHFFFAOYSA-N

Description

Descripción general

A highly potent, selective, and orally bioavailable non-xanthine adenosine A_2A receptor antagonist (K_i = 800 pM for human adenosine A_2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A₁, A_2B (K_i = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A₃R (K_i >10 µM in human A₃R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (K_i = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Acciones bioquímicas o fisiológicas

Primary Target
A2A

Reversible: yes

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Poucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.

Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable