Merck
All Photos(3)

1.37030

SAFC

Urea

crystalline, EMPROVE® EXPERT, Ph. Eur., BP, JP, USP, ACS

Synonym(s):
Carbamide, Carbonyl diamide, Diaminomethanone, Carbonyldiamine, Carbamide, Carbonyldiamide
Linear Formula:
NH2CONH2
CAS Number:
Molecular Weight:
60.06
Beilstein:
635724
Número MDL:
Número índice de la CE:
200-315-5

grado

ACS reagent

Nivel de calidad

500

Agency

BP
JP
Ph. Eur.
USP

presión de vapor

<0.1 hPa ( 20 °C)

Línea del producto

EMPROVE® EXPERT

ensayo

98.0-102.0% (HPLC)

formulario

crystalline
solid

technique(s)

API processing | cocrystal formation: suitable

pH

9 (20 °C, 100 g/L in H2O)

mp

132-135 °C (lit.)

densidad

1.335 g/mL at 25 °C (lit.)

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

temp. de almacenamiento

2-30°C

SMILES string

NC(N)=O

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

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Descripción general

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Urea is typically used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. It is useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. Urea may be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.
Due to its low microbial and endotoxin limits, Urea cryst. Emprove® Expert is especially suitable for high-risk applications.
Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Envase

1, 5 kg in PE bottle
12 kg in PE bag (in PE pail)
25 kg in PE bag (in PE square drum)
25 kg in double PE bag (DPES in carton)

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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