Merck
  • 373403
All Photos(2)

373403

Sigma-Aldrich

InSolution Hh/Gli Antagonist, GANT61

The InSolution Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

All Photos(2)
Synonym(s):
InSolution Hh/Gli Antagonist, GANT61, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl) bis(methylene) bis(N,N-dimethylaniline), NSC 136476, 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline
Empirical Formula (Hill Notation):
C27H35N5
CAS Number:
500579-04-4
Molecular Weight:
429.60
Número MDL:
MFCD14635408

Nivel de calidad

100

Análisis

≥95% (HPLC)

formulario

liquid

manufacturer/tradename

Calbiochem®

condiciones de almacenamiento

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

enviado en

dry ice

temp. de almacenamiento

−20°C

SMILES string

CN(C)C1=CC=CC=C1CN2CCCN(CC3=CC=CC=C3N(C)C)C2C4=CC=NC=C4

InChI

1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3

InChI key

KVQOGDQTWWCZFX-UHFFFAOYSA-N

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373400341249566324
InSolution Hh/Gli Antagonist, GANT61 The InSolution Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

373403

InSolution Hh/Gli Antagonist, GANT61

Hh/Gli Antagonist, GANT58 The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

373400

Hh/Gli Antagonist, GANT58

FAAH Inhibitor II The FAAH Inhibitor II, also referenced under CAS 546141-08-6, controls the biological activity of FAAH. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

341249

FAAH Inhibitor II

SIRT2 Inhibitor, AGK2 The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

Sigma-Aldrich

566324

SIRT2 Inhibitor, AGK2

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (NMR)

assay

≥95% (HPLC)

form

liquid

form

solid

form

crystalline solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

shipped in

dry ice

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Descripción general

A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (>Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available.

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
Gli1 and Gli2

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Forma física

A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

10 - Combustible liquids

WGK

WGK 2

Punto de inflamabilidad F

188.6 °F - (refers to pure substance)

Punto de inflamabilidad C

87 °C - (refers to pure substance)

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