410957

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).

• Synonym(s): 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem, IBMX
• Empirical Formula (Hill Notation): C₁₀H₁₄N₄O₂
• CAS Number: 28822-58-4
• Molecular Weight: 222.24
• Número MDL: MFCD00005584

Properties

• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: solid
• manufacturer/tradename: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: ethanol: 10 mg/mL; DMSO: 100 mM; methanol: 50 mg/mL
• enviado en: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
• InChI key: APIXJSLKIYYUKG-UHFFFAOYSA-N

Description

Descripción general

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.

A non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.

Envase

250 mg in Plastic ampoule

1 g in Plastic ampoule

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
cAMP and cGMP phosphodiesterases

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2-50 µM against cAMP and cGMP phosphodiesterases

Advertencia

Toxicity: Standard Handling (A)

Nota de preparación

Heating may be required to achieve complete solubilization.

Reconstitución

Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.

Otras notas

Hube, F., et al. 1999. Horm. Metab. Res.31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol.45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA76, 4451.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable