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525185

Sigma-Aldrich

Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem

The Phospholipase C Activator, m-3M3FBS, also referenced under CAS 200933-14-8, controls the biological activity of Phospholipase C. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Synonym(s):
Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem, m-3M3FBS, 2,4,6-Trimethyl-N-( m-3-trifluoromethylphenyl)benzenesulfonamide, m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
Empirical Formula (Hill Notation):
C16H16F3NO2S
CAS Number:
Molecular Weight:
343.36
Número MDL:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥95% (HPLC)

formulario

solid

manufacturer/tradename

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

off-white

solubilidad

DMSO: 7 mg/mL

enviado en

ambient

temp. de almacenamiento

2-8°C

InChI

1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

InChI key

ZIIUUSVHCHPIQD-UHFFFAOYSA-N

Descripción general

A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca2+ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.
A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.

Envase

10 mg in Plastic ampoule
Packaged under inert gas

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
Phospholipase C (PLC)
Product does not compete with ATP.
Reversible: no

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Otras notas

Bae, Y.S., et al. 2003. Mol. Pharmacol.63, 1043.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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