5291

Sigma-Aldrich

Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

Sinónimos:
Aerosporin, Polymyxin B Sulfate - CAS 1405-20-5 - Calbiochem
Número de CAS:
Número MDL:
NACRES:
NA.77

storage conditions

+15C to +30C

Nivel de calidad

200
100

formulario

solid

manufacturer/tradename

Calbiochem®

condiciones de almacenamiento

OK to freeze

color

white to off-white

solubilidad

water: 25 mg/mL

enviado en

ambient

temp. de almacenamiento

10-30°C

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

Descripción general

An antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.
An antibiotic that inhibits phospholipid-sensitive Ca2+-dependent protein kinases. Mixture of polymyxin B1 sulfate and polymyxin B2 sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.

Envase

500 mg in Plastic ampoule
1, 5 g in Plastic ampoule

Acciones bioquímicas o fisiológicas

Potency: ≥7500 IU/mg
Primary Target
Phospholipid sensitive Ca2+ dependent protein kinases

Advertencia

Toxicity: Harmful (C)

Otras notas

Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

storage_class_code

11 - Combustible Solids

WGK Alemania

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Anna M Bischofberger et al.
Environmental microbiology, 22(7), 2664-2679 (2020-03-13)
Bacteria in nature often encounter non-antibiotic antibacterials (NAAs), such as disinfectants and heavy metals, and they can evolve resistance via mechanisms that are also involved in antibiotic resistance. Understanding whether susceptibility to different types of antibacterials is non-randomly associated across...
Gina K Thomson et al.
PloS one, 14(12), e0220586-e0220586 (2019-12-12)
Carbapenemase-producing organisms (CPOs) are Gram-negative bacteria that are typically resistant to most or all antibiotics and are responsible for a global pandemic of high mortality. Rapid, accurate detection of CPOs and the classification of their carbapenemases are valuable tools for...

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