Merck
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567630

Sigma-Aldrich

Sodium Salicylate - CAS 54-21-7 - Calbiochem

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

Synonym(s):
Sodium Salicylate - CAS 54-21-7 - Calbiochem, Salicylic Acid, Na, NaSal
Empirical Formula (Hill Notation):
C7H5O3 · Na
CAS Number:
Molecular Weight:
160.10
Número MDL:

Nivel de calidad

100

ensayo

≥98% (titration)

formulario

solid

manufacturer/tradename

Calbiochem®

condiciones de almacenamiento

OK to freeze
desiccated (hygroscopic)

color

off-white

solubilidad

water: 50 mg/mL
ethanol: soluble

enviado en

ambient

temp. de almacenamiento

10-30°C

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

Descripción general

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

Envase

5 g in Glass bottle
Packaged under inert gas

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
Product does not compete with ATP.
Reversible: no

Advertencia

Toxicity: Harmful (C)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictogramas

Exclamation markHealth hazard

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

208.9 °F - Pensky-Martens closed cup

Punto de inflamabilidad C

98.3 °C - Pensky-Martens closed cup

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