Merck
  • 609315M
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609315-M

Millipore

Thyroid Hormone Receptor Antagonist, 1-850

The Thyroid Hormone Receptor Antagonist, 1-850, also referenced under CAS 251310-57-3, controls the biological activity of Thyroid Hormone Receptor. This small molecule/inhibitor is primarily used for Neuroscience applications.

All Photos(1)
Synonym(s):
Thyroid Hormone Receptor Antagonist, 1-850, TR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
Empirical Formula (Hill Notation):
C21H20F3N5O4
CAS Number:
251310-57-3
Molecular Weight:
463.41

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

solid

manufacturer/tradename

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

yellow

solubilidad

DMSO: 5 mg/mL

temp. de almacenamiento

2-8°C

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Thyroid Hormone Receptor Antagonist, 1-850 The Thyroid Hormone Receptor Antagonist, 1-850, also referenced under CAS 251310-57-3, controls the biological activity of Thyroid Hormone Receptor. This small molecule/inhibitor is primarily used for Neuroscience applications.

Millipore

609315-M

Thyroid Hormone Receptor Antagonist, 1-850

Glucagon Receptor Antagonist II The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.

Sigma-Aldrich

346003

Glucagon Receptor Antagonist II

PAF Receptor Antagonist, ABT-491 The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications.

Sigma-Aldrich

511071

PAF Receptor Antagonist, ABT-491

Thyrotropin releasing hormone ≥98% (HPLC), powder

Sigma-Aldrich

P1319

Thyrotropin releasing hormone

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

color

yellow

color

light beige

color

off-white

color

-

solubility

DMSO: 5 mg/mL

solubility

DMSO: 45 mg/mL, ethanol: 45 mg/mL

solubility

water: 10 mg/mL

solubility

water: 25 mg/mL, cloudy, colorless to faintly yellow

Descripción general

A cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRα with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor α (RARα) activity.
A cell-permeable, selective, high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Reported to block T3-L-triiodothyronine)-mediated interaction of TRα with nuclear receptor coactivator (NRC) and prevent stimulation of gene expression. Exhibits no antagonistic effects on retinoic acid receptor α (RARα) activity.

Acciones bioquímicas o fisiológicas

Primary Target
Thyroid Hormone Receptor
Target IC50: 1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7354.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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