Rachel Comba et al.
F1000Research, 4, 396-396 (2016-03-01)
Improvement on spatial tasks is observed during a late, postnatal developmental period (PND18 - PND24). The purpose of the current work was 1) to determine whether the emergence of spatial-behavioral function was based on the ability to generate appropriate behavioral...
Stuart D Portbury et al.
Journal of Alzheimer's disease : JAD, 60(2), 549-560 (2017-09-05)
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a...
Scott D Z Eggers et al.
PloS one, 10(7), e0132075-e0132075 (2015-07-03)
Perineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role. Within the ocular motor system, excitatory...
Yongfang Chen et al.
Environmental toxicology, 31(12), 1720-1730 (2015-07-29)
The objective of this study is to understand the impairment of learning and memory in mouse after chronic nitrite exposure. The animal model of nitrite exposure in mouse was created with the daily intubation of nitrite in adult healthy male...
Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease.
Camboni, M; Wang, CM; Miranda, C; Yoon, JH; Xu, R; Zygmunt, D; Kaspar, BK; Martin, PT
Neurobiology of Disease null