ABD28

Sigma-Aldrich

Anti-Rfx6 Antibody

serum, from rabbit

Sinónimos:
DNA-binding protein RFX6, Regulatory factor X 6, Regulatory factor X domain-containing protein 1
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

serum

antibody product type

primary antibodies

clon

polyclonal

species reactivity

mouse

aplicaciones

immunohistochemistry: suitable

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

Descripción general

Rfx6 (regulatory factor X 6) is a winged-helix transcription factor that is essential for development and seems to be located exclusively in the pancreatic islets. It has been associated with endoderm development, specifically, and the differentiation of islet cells. Since insulin production happens in the beta-cells of pancreatic islets, Rfx6 may be used clinically to treat diabetes. Recently, Rfx6 function has been found to change over time and gets restricted to endocrine cells at later stages. Mitchell-Riley syndrome is thought to stem from a Rfx6 mutation.

Inmunógeno

GST-tagged recombinant protein corresponding to mouse Rfx6.

Aplicación

Research Category
Stem Cell Research
Research Sub Category
Transcription Factors
Anti-Rfx6 Antibody is a Rabbit Polyclonal Antibody for detection of Rfx6 also known as DNA-binding protein RFX6, Regulatory factor X 6 & has been validated in IHC.

Calidad

Evaluated by Immunohistochemistry in mouse embryo pancreas tissue.

Immunohistochemistry Analysis: 1:400 dilution of this antibody detected Rfx6 in mouse embryo pancreas tissue.

Descripción de destino

102 kDa calculated. Additional isoforms at 59 and 73 kDa have also been reported.

Forma física

Unpurified
Rabbit polyclonal serum containing 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Nota de análisis

Control
Mouse embryo pancreas tissue

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

WGK 1

Certificado de Análisis
Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.
Suzuki, K; Harada, N; Yamane, S; Nakamura, Y; Sasaki, K; Nasteska, D; Joo, E; Shibue et al.
The Journal of Biological Chemistry null

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