ABE556

Sigma-Aldrich

Anti-Methyltransferase-like protein 13 Antibody

from rabbit, purified by affinity chromatography

Sinónimos:
Methyltransferase-like protein 13
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

antibody product type

primary antibodies

clon

polyclonal

purificado por

affinity chromatography

species reactivity

mouse, rat, human

species reactivity (predicted by homology)

primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

aplicaciones

immunoprecipitation (IP): suitable
western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

Descripción general

The protein named Methyltransferase-like protein 13 and encoded by the gene METTL13/KIAA0859, acts as a methyltransferase that is often up regulated in tumor tissue. Interestingly polymorphisms in the gene for METTL13 have also been associated with post-partum depression. Other members of this family catalyze important methylation reactions including the methylation of 7-methylguanosine in tRNA metabolism. Methyltransferase-like protein 13 is just one of several hundred family members and its expression is associated with many important events during embryonic development, growth and maturation but its actual function is still being discovered. Methyltransferase-like protein 13 is one of many genes that is highly conserved in eukaryotic development from worms to humans, thus its function is likely critical to some aspect of mammalian homeostasis.

Especificidad

This antibody witll detect isoforms 1, 2, 3, and 4 based on immunogen design.

Inmunógeno

KLH-conjugated linear peptide corresponding to the C-terminus of human Methyltransferase-like protein 13.
Epitope: C-terminus

Aplicación

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated Methyltransferase-like protein 13 in 500 µg of SK-OV-3 cell lysate.
This Anti-Methyltransferase-like protein 13 Antibody is validated for use in western blotting & IP for the detection of Methyltransferase-like protein 13.

Calidad

Evaluated by Western Blotting in SK-OV-3 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Methyltransferase-like protein 13 in 10 µg of SK-OV-3 cell lysate.

Descripción de destino

~58 kDa observed

Forma física

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity Purfied

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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