The protein named Methyltransferase-like protein 13 and encoded by the gene METTL13/KIAA0859, acts as a methyltransferase that is often up regulated in tumor tissue. Interestingly polymorphisms in the gene for METTL13 have also been associated with post-partum depression. Other members of this family catalyze important methylation reactions including the methylation of 7-methylguanosine in tRNA metabolism. Methyltransferase-like protein 13 is just one of several hundred family members and its expression is associated with many important events during embryonic development, growth and maturation but its actual function is still being discovered. Methyltransferase-like protein 13 is one of many genes that is highly conserved in eukaryotic development from worms to humans, thus its function is likely critical to some aspect of mammalian homeostasis.
This antibody witll detect isoforms 1, 2, 3, and 4 based on immunogen design.
KLH-conjugated linear peptide corresponding to the C-terminus of human Methyltransferase-like protein 13.
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated Methyltransferase-like protein 13 in 500 µg of SK-OV-3 cell lysate.
Epigenetics & Nuclear Function
Research Sub Category
This Anti-Methyltransferase-like protein 13 Antibody is validated for use in western blotting & IP for the detection of Methyltransferase-like protein 13.
Evaluated by Western Blotting in SK-OV-3 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected Methyltransferase-like protein 13 in 10 µg of SK-OV-3 cell lysate.
Descripción de destino
~58 kDa observed
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt.
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.