ABT49

Sigma-Aldrich

Anti-Dynamin-2 Antibody

serum, from rabbit

Sinónimos:
dynamin 2, dynamin II, dynamin-2
eCl@ss:
32160702

origen biológico

rabbit

Nivel de calidad

100

forma del anticuerpo

serum

antibody product type

primary antibodies

clon

polyclonal

species reactivity

human

aplicaciones

western blot: suitable

isotipo

IgG

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

Descripción general

Dynamin-2 is a ubiquitously expressed, membrane associated protein belonging to the Dynamin protein family of GTPases, a group consisting of three isoforms with distinct tissue specificity and function. Dynamin localizes to plasma membrane-coated pits by its interactions with amphiphysin through the dynamin PRD domain. Dynamin-2 is a component in the manufacture of microtubule bundles, and is capable of both binding and hydrolyzing GTP. It is also likely to be involved in the trafficking mechanisms for vesicles, especially those pertaining to endocytosis. Defects in the expression of Dynamin-2 have been shown to cause Charcot-Marie-Tooth disease dominant intermediate type B (CMTDIB), and centronuclear myopathy autosomal dominant (ADCNM). There is also some interest in Dynamin-2 as a potential regulator for adenovirus targeting cancer therapies.

Inmunógeno

KLH-conjugated linear peptide corresponding to human Dynamin-2.

Aplicación

Research Category
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Detect Dynamin-2 using this Anti-Dynamin-2 Antibody validated for use in WB.

Calidad

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1:1,000 dilution of the antibody detected Dynamin-2 in 10 µg of HeLa cell lysate.

Descripción de destino

~ 98 kDa observed

Forma física

Rabbit polyclonal serum containing 0.5% sodium azide.
Unpurified

Almacenamiento y estabilidad

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Nota de análisis

Control
HeLa cell lysate

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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