CBL517

Sigma-Aldrich

Anti-CD28 Antibody, clone 15E8

clone 15E8, Chemicon®, from mouse

Sinónimos:
Tp44
eCl@ss:
32160702
NACRES:
NA.41

Nivel de calidad

100

origen biológico

mouse

antibody product type

primary antibodies

clon

15E8, monoclonal

species reactivity

human

should not react with

canine

manufacturer/tradename

Chemicon®

aplicaciones

flow cytometry: suitable

isotipo

IgG1

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

Gene Information

human ... CD28(940)

Especificidad

This antibody reacts with the 44 kDa antigen found on a sub-population of T cells and activated B cells. These CD28+ CD8 cells are now known to be cytotoxic T cell precursors. The antibody does not react with B cells, granulocytes or monocytes. The ligand for CD28 is CD80 (B7) which is found on activated B cells suggesting a role for CD28 in T and B cell interaction

FUSION PARTNER: SP2/0

Inmunógeno

Human T lymphocytes

Aplicación

To study the role of CD28 in T cell proliferation. The antibody will induce the proliferation of resting T lymphocytes.

This antibody will act in cell stimulation studies where it has been suggested that measuring T cell function in HIV infected asymptomatic patients may be an early indicator of AIDS, independent of CD4 + cell counts

Optimal working dilutions must be determined by the end user.
This Anti-CD28 Antibody, clone 15E8 is validated for use in FC, FUNC for the detection of CD28.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

Ligadura / enlace

Replaces: CBL517P

Forma física

Please see lot specific datasheet for product formulation. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Format: Purified

Almacenamiento y estabilidad

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

nwg

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis
Antithymidylate resistance enables transgene selection and cell survival for T cells in the presence of 5-fluorouracil and antifolates.
Rushworth, et al.
Gene Therapy, 23, 119-128 (2018)
Eduardo Huarte et al.
Blood, 112(4), 1259-1268 (2008-06-14)
Robust T-cell responses without autoimmunity are only possible through a fine balance between activating and inhibitory signals. We have identified a novel modulator of T-cell expansion named proliferation-induced lymphocyte-associated receptor (PILAR). Surface PILAR is markedly up-regulated on CD4 and, to...
Maria C Lebre et al.
Journal of leukocyte biology, 101(3), 775-783 (2016-10-14)
Bone and cartilage destruction is one of the key manifestations of rheumatoid arthritis (RA). Although the role of T helper (Th)17 cells in these processes is clear, the role of IL-21-producing cells T cells has been neglected. We sought to...

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