GF338

Sigma-Aldrich

IL-6,
Human Recombinant Animal Free

Sinónimos:
Interleukin-6, IL6
eCl@ss:
32160405

impurezas

<0.1 μg/mg protein endotoxin (<1 EU/μg)

Nivel de calidad

100

Nº de acceso UniProt

enviado en

dry ice

Categorías relacionadas

Descripción general

Product Source: Protein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through
the IL-6 receptor system that consists of two chains, IL-6R and gp130. Murine IL-6 is inactive on human cells, while both
human and murine are equally active on murine cells.
Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Aplicación

Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors

Calidad

Determined by its ability to stimulate the proliferation of the IL-6 dependent mouse 7TD1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.

Forma física

Product is presented in 10mM Sodium Phosphate, pH 7.5 and is filtered through a 0.2 micron filter before lyophilization.

Almacenamiento y estabilidad

Store at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-0.5 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

WGK 1

Ruo-Yu Chen et al.
Cell death and differentiation, 27(4), 1259-1273 (2019-09-13)
Centrosomal P4.1-associated protein (CPAP) is overexpressed in hepatocellular carcinoma (HCC) and positively correlated with recurrence and vascular invasion. Here, we found that CPAP plays an important role in HCC malignancies. Functional characterization indicated that CPAP overexpression increases tumor growth, angiogenesis...

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