MAB362

Sigma-Aldrich

Anti-MAP1 Antibody, clone HM-1

ascites fluid, clone HM-1, Chemicon®

Sinónimos:
Microtubule-Associated Protein
eCl@ss:
32160702
NACRES:
NA.41

Nivel de calidad

100

origen biológico

mouse

forma del anticuerpo

ascites fluid

antibody product type

primary antibodies

clon

HM-1, monoclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Chemicon®

aplicaciones

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotipo

IgG1

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

dry ice

Gene Information

human ... MAP1A(4130)

Especificidad

Reacts specifically with MAP1 (also known as MAP 1a) on immunoblots of whole brain homogenate proteins. Shows selective staining of neurons and stronger staining of axons and dendrites in immunohistochemistry staining of brain tissue. Stains both the cell bodies and dendritic trees. No cross-reactivity observed to other MAPs or tubulin.

Inmunógeno

Rat brain microtubule-associated protein.

Aplicación

Research Sub Category
Neuronal & Glial Markers
Research Category
Neuroscience
Immunoblotting at 1:500 using fresh rat brain extract or enriched microtubule protein preparation.

Immunocytochemistry

Optimal working dilutions must be determined by end user.
Detect MAP1 using this Anti-MAP1 Antibody, clone HM-1 validated for use in WB, IC, IH.

Forma física

Ascites fluid. Liquid containing 15mM sodium azide.

Almacenamiento y estabilidad

Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

nwg

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

R M Douglas et al.
Neuroscience, 139(4), 1249-1261 (2006-03-29)
Large-conductance voltage- and calcium-sensitive channels are known to be expressed in the plasmalemma of central neurons; however, recent data suggest that large-conductance voltage- and calcium-sensitive channels may also be present in mitochondrial membranes. To determine the subcellular localization and distribution...
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 50(6), 2824-2838 (2009-01-27)
Cytoskeleton proteins play a critical role in maintaining retinal ganglion cell structure, viability, and function. This study documents the distribution of cytoskeleton protein subunits in the various regions of the normal human optic nerve and identifies important relationships among mitochondria...
Alejandra Bosco et al.
The Journal of comparative neurology, 519(4), 599-620 (2011-01-20)
Changes in microglial cell activation and distribution are associated with neuronal decline in the central nervous system (CNS), particularly under pathological conditions. Activated microglia converge on the initial site of axonal degeneration in human glaucoma, yet their part in its...
G Huber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 4(1), 151-160 (1984-01-01)
The distribution of microtubule-associated proteins (MAPs) 1 and 2 in rat brain was studied using monoclonal antibodies. Immunochemical staining showed that both MAP1 and MAP2 are present only in neurons and both are highly concentrated in dendrites compared to axons....
Kristin Kathleen Baxter et al.
ASN neuro, 1(4) (2009-09-12)
Mitochondria play a central role during neurogenesis by providing energy in the form of ATP for cytoskeletal remodelling, outgrowth of neuronal processes, growth cone activity and synaptic activity. However, the fundamental question of how differentiating neurons control mitochondrial biogenesis remains...

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