Merck
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2106

Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

endotoxin, free

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Número de CAS:
9041-08-1
Número MDL:
MFCD00081689
NACRES:
NA.21

origen biológico

Porcine intestinal mucosa

Nivel de calidad

200

formulario

powder

uso

sufficient for 5 mL blood anticoagulant

envase

preweighed vial of 300 USP units

impurezas

endotoxin, free

solubilidad

water: soluble 50 g/L
acetone: insoluble
alcohol: insoluble
benzene: insoluble
chloroform: insoluble
diethyl ether: insoluble

compatibilidad

for use with E-Toxate™

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Categorías relacionadas

Aplicación

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.

Acciones bioquímicas o fisiológicas

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.

Precaución

Not for injection.

Información legal

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificado de Análisis

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Certificado de origen

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Overexpression of Functional SLC6A3 in Clear Cell Renal Cell Carcinoma.
Jennifer Hansson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(8), 2105-2115 (2016-09-25)
Mechanism of the anticoagulant action of heparin.
I Björk et al.
Molecular and cellular biochemistry, 48(3), 161-182 (1982-10-29)
D Beeler et al.
The Journal of biological chemistry, 254(8), 2902-2913 (1979-04-25)
Preparations of low molecular weight porcine heparin with an average specific anticoagulant activity of 94 units/mg were fractionated into "active" and "relatively inactive" forms of the mucopolysaccharide of approximately 6000 daltons each. The active fraction was further subdivided into various
Nada M S Al-Saffar et al.
British journal of cancer, 119(9), 1118-1128 (2018-11-01)
AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT signalling would result in metabolic changes that could potentially be
L B Schwartz et al.
The Journal of biological chemistry, 261(16), 7372-7379 (1986-06-05)
Tryptase was shown to be stabilized as an enzymatically active tetramer by association with heparin and dissociated to inactive monomers in the absence of heparin at 37 degrees C in physiologic buffer and in plasma. There was a 50% loss
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