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62929

Sigma-Aldrich

L-Lysine monohydrochloride

BioUltra, ≥99.5% (AT)

Sinónimos:
(S)-2,6-Diaminohexanoic acid monohydrochloride
Fórmula lineal:
H2N(CH2)4CH(NH2)CO2H·HCl
Número de CAS:
Peso molecular:
182.65
Beilstein:
3563889
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.26

línea de producto

BioUltra

Nivel de calidad

200

ensayo

≥99.5% (AT)

formulario

powder or crystals

actividad óptica

[α]20/D +20.5±0.5°, c = 5% in 5 M HCl

aplicaciones

cell culture | mammalian: suitable

impurezas

insoluble matter, passes filter test
≤0.3% foreign amino acids

residuo de ign.

≤0.1% (as SO4)

pérdida

≤0.5% loss on drying, 20 °C (HV)

color

white

pH

5.0-6.0 (25 °C, 0.5 M in H2O)

mp

263 °C (dec.) (lit.)

solubilidad

H2O: 0.5 M at 20 °C, clear, colorless

trazas de anión

sulfate (SO42-): ≤100 mg/kg

trazas de catión

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤100 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.5 M in H2O

Absorción UV

λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1

SMILES string

OC([C@@H](N)CCCCN)=O.[H]Cl

InChI

1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1

InChI key

BVHLGVCQOALMSV-JEDNCBNOSA-N

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Descripción general

L-Lysine is an essential amino acid, not generated by the body, instead must be supplemented through food.

Aplicación

L-Lysine monohydrochloride has been used:
  • to study its effect on mRNA decay and destruction using mammalian cells
  • to determine its effec on aTC1-6 cell proliferation
  • to study the dynamics of the phosphoproteome upon amino acid supplement removal in the growth medium

Acciones bioquímicas o fisiológicas

L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is believed to prevent osteoporosis of bones, which is a characteristic of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Hydroxylysine is a component of collagen

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificado de Análisis

Certificado de origen

Amino acid transporter Slc38a5 controls glucagon receptor inhibition-induced pancreatic alpha cell hyperplasia in mice
Kim J, et al.
Cell Metabolism, 25(6), 1348-1361 (2017)
Characterization of early autophagy signaling by quantitative phosphoproteomics
Rigbolt KTG, et al.
Autophagy, 10(2), 356-371 (2014)
ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation
Sundaramoorthy E, et al.
Molecular Cell, 65(4), 751-760 (2017)
Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I.
Posset R
Journal of inherited metabolic disease, 38(2), 265-272 (2015)
Dietary l-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats
Akihiro Shimomura
Journal of the American Society of Nephrology, 25(9), 1954-1965 (2014)

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