81845

Sigma-Aldrich

Propidium iodide

≥94% (HPLC)

Sinónimos:
3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide
Empirical Formula (Hill Notation):
C27H34I2N4
Número de CAS:
Peso molecular:
668.39
Beilstein/REAXYS Number:
3843838
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

200

ensayo

≥94% (HPLC)

mp

220-225 °C (dec.) (lit.)

fluorescencia

λex 482 nm; λem 608 nm (pH 7.2)
λex 540 nm; λem 608 nm (bound to DNA)

temp. de almacenamiento

2-8°C

SMILES string

[I-].[I-].CC[N+](C)(CC)CCC[n+]1c(-c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14

InChI

1S/C27H33N4.2HI/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20;;/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3;2*1H/q+1;;/p-1

InChI key

XJMOSONTPMZWPB-UHFFFAOYSA-M

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Descripción general

Propidium iodide is a fluorescent intercalating agent used for staining. It functions as an apoptosis marker and has linear DNA-binding capacity. Propidium iodide is an effective indicator of tissue injury.
PI is used for selective labelling of dead cells.

Aplicación

in scrape-loading dye transfer assay
Propidium iodide has been used:
  • to stain DNA in cell cycle analysis
  • to stain cells and cell nuclei
  • for the preparation of propidium iodide (PI)stock solution
  • to stain cells for flow cytometry

Envase

25, 100 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictogramas

Health hazard

Palabra de señalización

Warning

Frases de peligro

hazcat

Muta. 2

storage_class_code

11 - Combustible Solids

WGK Alemania

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificado de Análisis

Certificado de origen

Flow cytometry (2008)
Differential nuclear staining assay for high-throughput screening to identify cytotoxic compounds
Carolina L, et al.
Current cellular biochemistry, 1(1), 1-1 (2011)
Effect of Different Combinations of the Growth Factors and Hormones on invitro Maturation of Goat Preantral Follicles
Shankaraiah P, et al.
International Journal of Current Microbiology and Applied Sciences, 7(4), 1956-1963 (2018)
Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator
Wang CK, et al.
Journal of Pineal Research, 63(4), e12440-e12440 (2017)
Antitumor effect of sunitinib in human prostate cancer cells functions via autophagy
Wang B, et al.
Experimental and Therapeutic Medicine, 13(4), 1285-1294 (2017)
Contenido relacionado
Three-dimensional (3D) printing of biological tissue is rapidly becoming an integral part of tissue engineering.
Más información
Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.
Más información

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