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NIST8671

NISTmAb, Humanized IgG1k Monoclonal Antibody

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NACRES:
NA.41

antibody product type

primary antibodies

grado

certified reference material

descripción

NIST® RM 8671

formulario

liquid

manufacturer/tradename

NIST®

technique(s)

UV/Vis spectroscopy: suitable
liquid chromatography (LC): suitable
mass spectrometry (MS): suitable

formato

matrix material

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R8779NISTRM8398NIST3667
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NIST3667

Creatinine in frozen human urine

form

liquid

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buffered aqueous solution

form

liquid

form

liquid

manufacturer/tradename

NIST®

manufacturer/tradename

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manufacturer/tradename

NIST®

manufacturer/tradename

NIST®

format

matrix material

format

-

format

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format

matrix material

antibody product type

primary antibodies

antibody product type

primary antibodies

antibody product type

-

antibody product type

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description

NIST® RM 8671

description

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description

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description

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Descripción general

NISTmAb, Humanized IgG1k Monoclonal Antibody is a recombinant antibody expressed in murine suspension culture. It is a homodimer with two identical light chains and two identical heavy chains linked through inter- and intra- chain disulfide bonds with a molecular weight of 150 kDa. The protein possesses a low abundance of post-translational modifications including methionine oxidation, deamidation, and glycation. This humanized monoclonal antibody also has N-terminal pyroglutamination, C-terminal lysine clipping, and glycosylation of the heavy chains.

A unit of RM 8671 consists of one internal-threaded polypropylene cryovial containing 800 µL of 10 mg/mL NIST IgG1κ monoclonal antibody (NISTmAb) in 12.5 mmol/L L-histidine, 12.5 mmol/L L-histidine HCl (pH 6.0).

SRM 8671_Cert
SRM 8671_SDS

Aplicación

NISTmAb, Humanized IgG1k Monoclonal Antibody has been used as a standard for testing de novo sequencing algorithms on bottom-up mass spectrometry.This reference material (RM) is primarily intended for evaluating the performance of methods for determining physiochemical and biophysical attributes of monoclonal antibodies. It also provides a representative test molecule for developing novel technology in therapeutic protein characterization. Other potential uses include:
  • system suitability tests
  • establishing method or instrument performance and variability
  • comparing changing analytical test methods
  • assisting in method qualification

Nota de análisis

NIST8671 is intended for research use. It is not intended for animal or human consumption, clinical testing or therapeutic use.

Otras notas

  • RM 8671 is intended for research use.
  • Details on expiration, storage, safety, usage, and source are provided in the NIST certificate. 
  • Information on biomaterials, disposal, and transport is available in the SDS.

Información legal

NIST is a registered trademark of National Institute of Standards and Technology

Producto relacionado

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Ioannis Karageorgos et al.
Biologicals : journal of the International Association of Biological Standardization, 50, 27-34 (2017-10-03)
Monoclonal antibody pharmaceuticals are the fastest-growing class of therapeutics, with a wide range of clinical applications. To assure their safety, these protein drugs must demonstrate highly consistent purity and stability. Key to these objectives is higher order structure measurements validated
Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery.
Sen K I, et al.
Journal of the American Society For Mass Spectrometry, 28(5), 803-810 (2017)

Artículos

Middle-Up Analysis of Antibodies by Reversed-Phase Chromatography

Comparative analysis of different columns in resolving medium-sized fragments of monoclonal antibodies, after digestion using dithiothreitol (DTT) or IdeS (a protease), by Reversed-Phase Chromatography.

A Comparison of Superficially Porous Particle-based Column Chemistries for Peptide Mapping

This application note compares three different column chemistries from the BIOshell™ line of columns with superficially porous particles to evaluate their performance in peptide mapping.

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