Pharmaceutical Secondary Standard; Certified Reference Material

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, Cortisol, Reichstein’s substance M, 4-Pregnene-11β,17α,21-triol-3,20-dione, 17-Hydroxycorticosterone, Kendall’s compound F
Empirical Formula (Hill Notation):
Número de CAS:
Peso molecular:
Beilstein/REAXYS Number:
Número de EC:
Número MDL:
ID de la sustancia en PubChem:

Nivel de calidad



certified reference material
pharmaceutical secondary standard


current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


211-214 °C (lit.)

Industria destacada

Pharmaceutical (small molecule)



trazabilidad farmacopeica

traceable to BP 576
traceable to PhEur H1300000
traceable to USP 1316004

SMILES string




InChI key


Gene Information

human ... NR3C1(2908)

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

Acciones bioquímicas o fisiológicas

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive.


Health hazard

Palabra de señalización


Frases de peligro


Repr. 1A - STOT RE 2


6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Alemania


Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Simultaneous determination of hydrocortisone and benzyl alcohol in pharmaceutical formulations by reversed-phase high-pressure liquid chromatography.
Rego Aand Nelson B
Journal of Pharmaceutical Sciences, 71(11), 1219-1223 (1982)
On-line post-column photochemical derivatization in liquid chromatographic− diode-array detection analysis of binary drug mixtures.
Di Pietra AM,et al
Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 1191-1199 (1996)
Advantages of application of UPLC in pharmaceutical analysis.
Novakova L, et al.
Talanta, 68(3), 908-918 (2006)
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)
Margriet A B Veldhorst et al.
The Journal of clinical endocrinology and metabolism, 99(1), 285-290 (2014-01-05)
Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children....

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