Merck
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PHR1057

Supelco

Furosemide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
FUR, 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Empirical Formula (Hill Notation):
C12H11ClN2O5S
CAS Number:
Molecular Weight:
330.74
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to BP 547
traceable to Ph. Eur. F0700000
traceable to USP 1287008

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

220 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Furosemide is classified under the group of loop diuretics. It is used for the prevention of hypertension linked to renal and cardiac insufficiency.

Aplicación

Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS). Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy.
Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry, spectrophotometry and high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Inhibits ion co-transport in the kidney.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA7130 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictogramas

Exclamation markHealth hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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