PHR1595

Supelco

Polymyxin B Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:
Polymyxin B sulfate
Número de CAS:
Número de EC:
NACRES:
NA.24

Nivel de calidad

300

grado

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

envase

pkg of 500 mg

aplicaciones

HPLC: suitable
gas chromatography (GC): suitable

Industria destacada

Pharmaceutical (small molecule)

formato

neat

trazabilidad farmacopeica

traceable to BP 1028
traceable to PhEur P2400000
traceable to USP 1547007

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

Descripción general

Polymyxin B Sulfate is used for the treatment of gram-negative bacterial infections caused particularly by Pseudomonas aeruginosa and Escherichia coli.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Polymyxin B Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography and capillary electrophoresis, respectively.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0300 in the slot below. This is an example certificate only and may not be the lot that you receive.

storage_class_code

13 - Non Combustible Solids

WGK Alemania

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

Simultaneous determination of neomycin sulfate and polymyxin B sulfate by capillary electrophoresis with indirect UV detection.
Srisom P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3), 1013-1018 (2007)
Sensitive detection of polymyxin B sulfate at the nanogram level using enhanced resonance scattering signals and decreased fluorescence signals with thioglycolic acid capped CdTe/CdS quantum dots as probe.
Shen Y, et al.
Sensors and Actuators B, Chemical, 188, 555-563 (2013)
Development of a liquid chromatographic method for ear drops containing neomycin sulphate, polymyxin B sulphate and dexamethasone sodium phosphate.
Pendela M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 751-757 (2004)

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