123M-2

Sigma-Aldrich

CD23 (MRQ-57) Mouse Monoclonal Antibody

NACRES:
NA.41

Nivel de calidad

500
100

origen biológico

mouse

forma del anticuerpo

culture supernatant

antibody product type

primary antibodies

clon

MRQ-57, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

species reactivity

human

envase

vial of 0.1 mL concentrate (123M-24)
vial of 0.5 mL concentrate (123M-25)
bottle of 1.0 mL predilute (123M-27)
vial of 1.0 mL concentrate (123M-26)
bottle of 7.0 mL predilute (123M-28)

manufacturer/tradename

Cell Marque

aplicaciones

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG2a

conjugado

unconjugated

control

chronic lymphocytic leukemia, lymph node, small lymphocytic lymphoma, tonsil

enviado en

wet ice

temp. de almacenamiento

2-8°C

visualización

membranous

Categorías relacionadas

Descripción general

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly.The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and B-cell Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL/SLL).

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

CD23 Positive Control Slides, Product No. 123S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

storage_class_code

12 - Non Combustible Liquids

WGK Alemania

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Certificado de origen

S Raghoebier et al.
Blood, 78(10), 2680-2685 (1991-11-15)
Large cell lymphomas (LCLs) are heterogeneous in morphology, clinical presentation, and behavior. We studied 52 de novo LCLs of B-cell type for rearrangements of the bcl-2 and c-myc oncogenes by Southern blot analysis and related these data to the primary...
D C Rowlands et al.
The Journal of pathology, 160(3), 239-243 (1990-03-01)
The leukocyte antigen CD23 is expressed during B-cell development, and functions as an IgE receptor and a lymphocyte growth factor. We studied the expression of CD23 in paraffin sections of lymphoid tissue using the monoclonal antibody BU38. Fifteen cases of...
Francesco DiRaimondo et al.
Cancer, 94(6), 1721-1730 (2002-03-29)
CD23 antigen is a cell surface protein considered important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias. To better clarify CD23 role as a diagnostic tool, the authors retrospectively evaluated clinical and laboratory features of 372...

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