123R-1

Sigma-Aldrich

CD23 (SP23) Rabbit Monoclonal Antibody

NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

500
100

forma del anticuerpo

culture supernatant

antibody product type

primary antibodies

clon

SP23, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

species reactivity

human

envase

vial of 0.1 mL concentrate (123R-14)
vial of 0.5 mL concentrate (123R-15)
bottle of 1.0 mL predilute (123R-17)
vial of 1.0 mL concentrate (123R-16)
bottle of 7.0 mL predilute (123R-18)

manufacturer/tradename

Cell Marque

aplicaciones

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG1

conjugado

unconjugated

control

tonsil

enviado en

wet ice

temp. de almacenamiento

2-8°C

visualización

membranous

Categorías relacionadas

Descripción general

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.1 Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/ macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and B-cell Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL/SLL).

Ligadura / enlace

CD23 Positive Control Slides, Product No. 123S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

RIDADR

NONH for all modes of transport

Certificado de Análisis
D C Rowlands et al.
The Journal of pathology, 160(3), 239-243 (1990-03-01)
The leukocyte antigen CD23 is expressed during B-cell development, and functions as an IgE receptor and a lymphocyte growth factor. We studied the expression of CD23 in paraffin sections of lymphoid tissue using the monoclonal antibody BU38. Fifteen cases of...
S Raghoebier et al.
Blood, 78(10), 2680-2685 (1991-11-15)
Large cell lymphomas (LCLs) are heterogeneous in morphology, clinical presentation, and behavior. We studied 52 de novo LCLs of B-cell type for rearrangements of the bcl-2 and c-myc oncogenes by Southern blot analysis and related these data to the primary...
Francesco DiRaimondo et al.
Cancer, 94(6), 1721-1730 (2002-03-29)
CD23 antigen is a cell surface protein considered important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias. To better clarify CD23 role as a diagnostic tool, the authors retrospectively evaluated clinical and laboratory features of 372...

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