388R-1

Sigma-Aldrich

Nestin (EP287) Rabbit Monoclonal Primary Antibody

origen biológico

rabbit

Nivel de calidad

500
100

forma del anticuerpo

culture supernatant

antibody product type

primary antibodies

clon

EP287, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

species reactivity

human

envase

vial of 0.1 mL concentrate (388R-14)
vial of 0.5 mL concentrate (388R-15)
vial of 1.0 mL concentrate (388R-16)
vial of 1.0 mL predilute ready-to-use (388R-17)
vial of 7.0 mL predilute ready-to-use (388R-18)

manufacturer/tradename

Cell Marque

concentración

0.1-0.5 μg/mL (predilute)
50-500 μg/mL (concentrate)

aplicaciones

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotipo

IgG

conjugado

unconjugated

control

tonsil

enviado en

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Categorías relacionadas

Descripción general

Nestin is a class VI intermediate filament (IF) protein. Nestin is expressed in neural progenitor cells during development of the central nervous system and peripheral nervous system. Cytoplasmic anti-nestin staining mostly occurs under pathological conditions. It has been reported that nestin expression is significantly increased in melanoma and correlated with more advanced stages of the disease. Nestin immunoreactivity is also reported in melanoma cells of HMB-45-negative amelanotic and melanotic, non-desmoplastic melanoma. Nestin is also useful in subclassifying breast carcinoma. Only cytoplasmic staining is considered positive, whereas any nuclear staining is considered as background artifact.

Calidad

Canada - IVD
European Union - IVD
Japan - RUO
United States - IVD

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

WGK Alemania

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis
Hua Li et al.
Cancer research, 67(2), 501-510 (2007-01-20)
Transcriptional profiling has identified five breast cancer subtypes, of which the basal epithelial is most aggressive and correlates with poor prognosis. These tumors display a high degree of cellular heterogeneity and lack established molecular targets, such as estrogen receptor-alpha, progesterone...
Svetlana Brychtova et al.
Journal of cutaneous pathology, 34(5), 370-375 (2007-04-24)
Nestin is one of the intermediate filaments that are expressed in proliferating neural progenitor cells during development of the central nervous system (CNS) and peripheral nervous system. Postnatal re-expression of the protein occurs mainly under pathological conditions, including injury and...
Maho Kanoh et al.
The Journal of dermatology, 37(6), 505-511 (2010-06-12)
Nestin, a marker of neural stem cells, is expressed in the stem cells of the mouse hair follicle. The nestin-expressing hair follicle stem cells can differentiate into neurons, glia, keratocytes, smooth muscle cells and melanocytes in vitro. These pluripotent nestin-expressing...

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico

Redes sociales

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Investigación. Desarrollo. Producción.

Somos un proveedor líder para la industria de Ciencias de la Vida con soluciones y servicios para investigación, desarrollo y producción biotecnológicos, y para desarrollo y producción de tratamientos farmacéuticos

© 2021 Merck KGaA, Darmstadt, Alemania y/o sus filiales. Todos los derechos reservados.

Queda estrictamente prohibida la reproducción sin permiso de cualquiera de los materiales de la página web.