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C2562

Sigma-Aldrich

Monoclonal Anti-Cytokeratin, pan (Mixture) antibody produced in mouse

clone C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2, ascites fluid

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Sinónimos:
Monoclonal Anti-Cytokeratin, pan (mixture), Panck Antibody, Panck Antibody - Monoclonal Anti-Cytokeratin, pan (Mixture) antibody produced in mouse
Número MDL:

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2, monoclonal

contiene

7% horse serum and 15 mM sodium azide as preservative

reactividad de especies

wide range

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using protease-digested sections of human or animal tissues
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:100 using protease-digested, formalin-fixed, paraffin-embedded sections of human or animal tissues
western blot: suitable

isotipo

IgG1/IgG2a

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

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Este artículo
C1801F3418C8541
biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2, monoclonal

clone

PCK-26, monoclonal

clone

C-11, monoclonal

clone

CY-90, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

FITC conjugate

conjugate

unconjugated

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

purified immunoglobulin

antibody form

ascites fluid

isotype

IgG1/IgG2a

isotype

IgG1

isotype

IgG1

isotype

IgG1

Descripción general

Monoclonal Anti-Cytokeratin, pan (mouse IgG1 and IgG2a isotypes) is a mixture of monoclonal antibodies from the following clones: C-11, PCK-26, CY-90, KS1A3, M20, and A53-B/A2. Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 1 (68 kDa), 4 (59 kDa), 5 (58 kDa), 8 (52 kDa), and 6 (56 kDa) are members of the type II neutral-to-basic subfamily expressed in cornified epithelia, non-cornified stratified squamous epithelia, stratified epithelia, simple epithelia and in tissues with natural or pathological turnover respectively. Cytokeratins 10 (56 kDa), 13 (54 kDa, and 18 (45 kDa) are members of the type I acidic subfamily expressed in cornified epithelia, non-cornified stratified squamous epithelia and simple epithelial cells respectively. Cytokeratin peptide 19 (40 kDa) is a type I keratin which can be expressed in both simple and in broad cells of stratifying epithelia at specific sites.

Especificidad

This is a mixture of monoclonal anti-cytokeratin antibodies. It recognizes human cytokeratins 1,4,5,6,8,10,13,18, and 19. It is a broad spectrum reagent, which reacts specifically with a wide variety of normal, reactive, and neoplastic epithelial tissues. The antibody mixture reacts with simple, cornifying and non-cornifying squamous epithelia and pseudostratified epithelia. It does not react with non-epithelial normal human tissues. Increased staining intensity is seen following proteolytic treatment (protease unmasking).

Inmunógeno

mixture of several monoclonal cytokeratin clones.

Aplicación

Monoclonal Anti-Cytokeratin, pan (Mixture) antibody produced in mouse is suitable for the following applications:
  • Immunohistochemistry (formalin-fixed, paraffin-embedded sections) using protease-digested sections of human or animal tissues.
  • Immunohistochemistry (frozen sections).
  • Indirect immunofluorescence (at a working dilution of 1:100 using protease-digested, formalin-fixed, paraffin-embedded sections of human or animal tissues).
  • Immunocytochemical labeling (immunofluorescence ) of cells.
  • Western blotting.

Acciones bioquímicas o fisiológicas

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in the epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3


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