Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis.
Jin J, Hu J, Zhou W, et al.
Biochemical Pharmacology, 90(1), 50-61 (2014)
C H Liu et al.
Molecular biology of the cell, 10(4), 1179-1190 (1999-04-10)
The endothelial-derived G-protein-coupled receptor EDG-1 is a high-affinity receptor for the bioactive lipid mediator sphingosine-1-phosphate (SPP). In the present study, we constructed the EDG-1-green fluorescent protein (GFP) chimera to examine the dynamics and subcellular localization of SPP-EDG-1 interaction. SPP binds...
Marco Antonio Morquecho-León et al.
Biochimica et biophysica acta, 1843(2), 327-334 (2013-11-19)
The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied. Activation of S1P1 receptors induced an immediate increase in intracellular calcium, which was blocked by preincubation with PMA....
M J Lee et al.
Science (New York, N.Y.), 279(5356), 1552-1555 (1998-03-21)
The sphingolipid metabolite sphingosine-1-phosphate (SPP) has been implicated as a second messenger in cell proliferation and survival. However, many of its biological effects are due to binding to unidentified receptors on the cell surface. SPP activated the heterotrimeric guanine nucleotide...
Michael J Kluk et al.
Laboratory investigation; a journal of technical methods and pathology, 93(4), 462-471 (2013-02-20)
Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed-Sternberg (HRS) cells), has been described to have a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes. Despite the progress made in understanding CHL pathophysiology...